We present a simple and new strategy to produce a thin collagen membrane with a natural microstructure from porcine tendons and reconstruct the functional cardiac tissues by recellularizing hiPSC-derived cardiomyocytes onto the membrane, for the first time. The obtained thin collagen membrane with a natural microstructure is analogous to the in vivo extracellular matrix structure and functions, supporting the good function of the engineered cardiac tissue.

Biomaterials Science, 2016, 4 (11), 1655-1662

A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumor

We proposed a new and dynamic in vivo-like three-dimensional microfluidic system that replicates the key structural, functional and mechanical properties of the blood-brain barrier in vivo. Multiple factors in this system work synergistically to accentuate BBB-specifc attributes–permitting the analysis of complex organ-level responses in both normal and pathological microenvironments in brain tumors.

Scientific Reports, 2016, 6, 36670

Simple Spinning of Heterogeneous Hollow Microfiber on Chip

We present a novel and simple chip-based microfluidic strategy for continuously controlled spinning of desirable hollow microfibers that simultaneously exhibit morphological and structural complexity and a heterogeneous composition. The use of a microfluidic chip enables the one-step production of multiple hollow microfibers with either multiple compartments or multiple components via the controllable formation of various multilayer jet flow patterns

Advanced Materials, 2016, 28(31),6649-+