欢迎访问中科院大连化学物理研究所 生物微流控系统研究组!

研究组简介

研究团队主要从事微流控器官芯片、类器官及其与生命科学的前沿交叉研究,融合工程学、材料、生物学、干细胞和医学等多学科交叉方法,开展人体重要组织器官(如脑、肝等)工程化构筑的新体系、新方法研究,研究建立具有高度生理相关的器官模拟微系统,以期在系统层面解析复杂性疾病(如糖尿病)的生理、病理过程及组织器官间互作,为组织器官发育、器官再造、疾病研究、毒性预测和药物研发等提供新的策略和技术平台。 团队拥有一支具有合作精神、开放思维和创新活力的年轻队伍,分别具有化学、生物学、医学、材料和工程学等多学科研究教育背景,并与国内外著名研究机构建立了长期合作关系。已系统建立了一系列具有自主知识产权的器官芯片技术和生... 【查看详情】

组长简介

秦建华,中科院大连化学物理研究所首席研究员,研究组组长;微流控芯片中心主任,辽宁省微流控芯片重点实验室主任,中国科学院大学未来技术学院生物芯片教研室副主任;中科院器官重建与制造A类战略性先导专项总体组专家;中科院脑科学与智能技术卓越创新中心骨干;中国生物工程学会生物传感与生物芯片专业委员会副主任委员,中国应用药理学会理事,中国毒理学会纳米毒理学专委会委员。中科院大连化学物理研究所获理学博士、中国医科大学医学本科,香港大学理学院... 【查看详情】

发表论文更多>>

    • Modeling Human Nonalcoholic Fatty Liver Disease (NAFLD) with an Organoids-on-chip System

      Yaqing Wang, Hui Wang, Pengwei Deng, Tingting Tao, Haitao Liu,Shuo Wu, Wenwen Chen and Jianhua Qin

      ACS Biomaterials Science & Engineering, 2020. DOI: 10.1021/acsbiomaterials.0c00682

    • One-step synthesis of composite hydogel capsule to support liver organoids generation from hiPSCs

      Yaqing Wang, Haitao Liu, Min Zhang, Hui Wang, Wenwen Chen and Jianhua Qin

      Biomaterials Science, 2020. DOI: 10.1039/D0BM01085E

    • Amnion-on-a-chip: modeling human amniotic development in mid-gestation from pluripotent stem cells

      Jianhua Qin, Yujuan Zhu, Hui Wang, Fangchao Yin, Yaqiong Guo, Fei Li, and Dong Gao

      Lab Chip, 2020. DOI: 10.1039/D0LC00268B

    • Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model

      Kangli Cui, Yaqing Wang, Yujian Zhu, Tingting Tao, Fangchao Yin, Yaqiong Guo, Haitao Liu, Fei Li, Peng Wang, Yuejun Chen and Jianhua Qin

      Microsyst. Nanoeng. 2020, 6, 49 DOI: 10.1038/s41378-020-0165-z

    • Flexible Generation of Multi-Aqueous Core Hydrogel Capsules Using Microfluidic Aqueous Two-Phase System

      Hui Wang, Haitao Liu, Fan He, Wenwen Chen, Xu Zhang, Mengqian Zhao, Li Wang, and Jianhua Qin

      Adv. Mater. Technol. 2020, 2000045. DOI: 10.1002/admt.202000045

    • A Droplet Microfluidic System to Fabricate Hybrid Capsules Enabling Stem Cell Organoid Engineering

      Haitao Liu, Yaqing Wang, Hui Wang, Mengqian Zhao, Tingting Tao, Xu Zhang, and Jianhua Qin

      Adv. Sci. 2020, 1903739. DOI: 10.1002/advs.201903739

    • Microfluidic device for on-chip isolation and detection of circulating exosomes in blood of breast cancer patients.

      Wenwen Chen, Hongjing Li, Wentao Su , and Jianhua Qin

      Biomicrofluidics. 2019, 13, 054113

    • Microfluidic strategies for label-free exosomes isolation and analysis

      Wentao Su, Hongjing Li, Wenwen Chen, and Jianhua Qin

      Trends in Analytical Chemistry. 2019, 118, 686-698

    • Integrated Microfluidic Device for Enrichment and Identification of Circulating Tumor Cells from the Blood of Patients with Colorectal Cancer.

      Wentao Su , Hao Yu, Lei Jiang, Wenwen Chen, Hongjing Li, and Jianhua Qin

      Disease Markers. 2019, 8945974. DOI: 10.1155/2019/8945974

    • Advances in Hydrogels in Organoids and Organs-on-a-Chip.

      Haitao Liu, Yaqing Wang, Kangli Cui, Yaqiong Guo, Xu Zhang, and Jianhua Qin

      Adv. Mater. 2019, 1902042. DOI: 10.1002/adma.201902042

    • Simple fabrication of inner chitosan‐coated alginate hollow microfiber with higher stability.

      Hui Liu, Yaqing Wang, Yue Yu, Wenwen Chen, Lei Jiang and Jianhua Qin

      J Biomed Mater Res Part B., 2019, 9999B, 1–10

    • One-Step Generation of Core-Shell Gelatin Methacrylate (GelMA) Microgels Using a Droplet Microfluidic System.

      Hui Wang, Haitao Liu, Hui Liu, Wentao Su, Wenwen Chen and Jianhua Qin

      Adv. Mater. Technol., 2019, 1800632,DOI: 10.1002/admt.201800632

    • Engineering human islet organoids from iPSCs using an organ-on-chip platform.

      Tingting Tao, Yaqing Wang, Wenwen Chen, Zhongyu Li, Wentao Su, Pengwei Deng and Jianhua Qin

      Lab Chip, 2019, 19, 948–958

    • In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system.

      Yaqing Wang, Hui Wang, Pengwei Deng, Wenwen Chen, Yaqiong Guo,Tingting Tao and Jianhua Qin.

      Lab on a Chip, 2018, DOI: 10.1039/c8lc00869h

    • A 3D human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier.

      Fangchao Yin, Yujuan Zhu, Min Zhang, Hao Yu, Wenwen Chen, Jianhua Qin.

      Toxicology in Vitro, 2018,54: 105-113

    • Stimulation of chondrocytes and chondroinduced mesenchymal stem cells by osteoinduced mesenchymal stem cells under a fluid flow stimulus on an integrated microfluidic device.

      Xuanwen Bao, Zhongyu Li, Hui Liu, Ke Feng, Fangchao Yin, Hongjing Li* and Jianhua Qin.

      Molecular Medicine Reports, 2018, 17 (2) :2277-2288

    • A 3D human lung-on-a-chip model for nanotoxicity testing.

      Min Zhang, Cong Xu, Lei Jiang and Jianhua Qin.

      Toxicology Research, 2018, 7, 1048-1060(cover image)

    • Placental Barrier-on-a-Chip: Modeling Placental Inflammatory Responses to Bacterial Infection.

      Yujuan Zhu, Fangchao Yin, Hui Wang, Li Wang, Jingli Yuan, and Jianhua Qin.

      ACS Biomaterials Science & Engineering, 2018, 4 (9) : 3356-3363

    • A Microfluidic Strategy for Controllable Generation of Water-in-Water Droplets as Biocompatible Microcarriers.

      Haitao Liu, Hui Wang, Wenbo Wei, Hui Liu, Lei Jiang, and Jianhua Qin.

      Small, 2018, 14 (36) : 1801095

    • A Biomimetic Human Gut-on-a-Chip for Modeling Drug Metabolism in Intestine.

      Yaqiong Guo, Zhongyu Li, Wentao Su, Li Wang, Yujuan Zhu, and Jianhua Qin.

      Artificial Organs, 2018, DOI:10.1111/aor.13163

    • Engineering brain organoids to probe impaired neurogenesis induced by cadmium.

      Yin, Fangchao, Yujuan Zhu, Yaqing Wang, and Jianhua Qin.

      ACS Biomaterials Science & Engineering, 2018, 4(5),1908-1915.

    • Human brain organoid-on-a-chip to model prenatal nicotine exposure.

      Yaqing Wang, Li Wang, Yujuan Zhu, and Jianhua Qin.

      Lab on a Chip, 2018, 18(6),851-860

    • Engineering stem cell-derived 3D brain organoids in a perfusable organ-on-a-chip system.

      Yaqing Wang, Li Wang, Yaqiong Guo, Yujuan Zhu and Jianhua Qin.

      RSC Advances, 2018, 8, 1677-1685

    • Probing impaired neurogenesis in human brain organoids exposed to alcohol.

      Yujuan Zhu, Li Wang, Fangchao Yin, Yue Yu, Yaqing Wang, Matthew J. Shepard, Zhengping Zhuang and Jianhua Qin.

      Integrative Biology, 2017,9, 968-978

    • Paper supported long-term 3D liver co-culture model for the assessment of hepatotoxic drugs.

      Yaqing Wang, Wentao Su, Li Wang, Lei Jiang, Yang Liu, Lijian Hui and Jianhua Qin.

      Toxicology Research, 2018, 7, 13-21 (Cover image)

    • Assessment of hepatic metabolism-dependent nephrotoxicity on an organs-on-a-chip microdevice.

      Zhongyu Li, Lei Jiang, Yujuan Zhu, Wentao Su, Cong Xu, Tingting Tao, Yang Shi and Jianhua Qin.

      Toxicology in Vitro, 2018, 46:1-8

    • Hollow Fiber System for Simple Generation of Human Brain Organoids.

      Yujuan Zhu, Li Wang, Fangchao Yin, Yue Yu, Yaqing Wang, Hui Liu, Hui Wang, Ning Sun, Haitao Liu and Jianhua Qin.

      Integrative Biology, 2017, 9, 774-781

    • In situ generation of human brain organoids on a micropillar array.

      Yujuan Zhu, Li Wang, Hao Yu, Fangchao Yin, Yaqing Wang, Haitao Liu, Lei Jiang and Jianhua Qin.

      Lab on a Chip, 2017, 17, 2941 - 2950

    • Bioinspired onion epithelium-like structure promotes the maturation of cardiomyocytes derived from human pluripotent stem cells.

      Cong Xu, Li Wang, Yue Yu, Fangchao Yin, Xiaoqing Zhang, Lei Jiang, Jianhua Qin.

      Biomaterials Science, 2017, 5, 1810 - 1819

    • Drug absorption related nephrotoxicity assessment on an intestine-kidney chip.

      Zhongyu Li, Wentao Su, Yujuan Zhu, Tingting Tao, Dong Li, Xiaojun Peng, and Jianhua Qin.

      Biomicrofluidics 11, 034114 (2017), DOI: http://dx.doi.org/10.1063/1.4984768

    • A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice.

      Li Wang,Tingting Tao, Wentao Su, Hao Yu, Yue Yu and Jianhua Qin

      Lab on a Chip, 2017, 17, 1749-1760(hot paper)

    • Assessment of cadmium-induced nephrotoxicity using a kidney-on-a-chip device.

      Zhongyu Li, Lei Jiang, Tingting Tao, Wentao Su, Yaqiong Guo, Hao Yu and Jianhua Qin

      Toxicology Research, 2017, 6, 372-380

    • Probing the Bi-directional Interaction Between Microgliaand Gliomas in a Tumor Microenvironment on a Microdevice.

      Rui Gu, Xu Zhang, Ge Zhang, Tingting Tao, Haibo Yu, Lianqing Liu, Ying Dou, Aiping Li, Jianhua Qin

      Neurochem Res, 2017, 42, 1478–1487

    • Human induced pluripotent stem cell-derived cardiac tissue on a thin collagen membrane with natural microstructures.

      Li Wang, Xiaoqing Zhang, Cong Xu, Hui Liu, Jianhua Qin.

      Biomaterials Science, 2016, 4 (11), 1655-1662

    • A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumor.

      Hui Xu, Zhongyu Li, Yue Yu, Saman Sizdahkhani, Winson S. Ho, Fangchao Yin, Li Wang, Guoli Zhu, Min Zhang, Lei Jiang, Zhengping Zhuang, and Jianhua Qin

      Scientific Reports, 2016, 6, 36670

    • Assessment of metabolism-dependent drug efficacyand toxicity on a multilayer organs-on-a-chip.

      Zhongyu Li, Yaqiong Guo, Yue Yu, Cong Xu, Hui Xu, and Jianhua Qin

      Integrative Biology, 2016,8,1022-1029 (Cover image)

    • Simple Spinning of Heterogeneous Hollow Microfiber on Chip.

      Yue Yu, Wenbo Wei, Yaqing Wang, Cong Xu, Yaqiong Guo, Jianhua Qin

      Advanced Materials, 2016, 28(31),6649-+

    • Human induced pluripotent stem cells derived endothelial cells mimicking vascular inflammatory response under flow.

      Li Wang, Meng Xiang, Yingying Liu, Ning Sun, Meng Lu, Yang Shi, Xinhong Wang, Dan Meng, Sifeng Chen, and Jianhua Qin

      Biomicrofluidics, 2016, 014106

    • Patterning hypoxic multicellular spheroids in a 3D matrix –a promising method for anti-tumor drug screening.

      Jingyun Ma, Xu Zhang, Yang Liu, Haibo Yu, Lianqing Liu, Yang Shi, Yanfeng Li and Jianhua Qin

      Biotechnology Journal, 2016,11(1),127-134

    • Modeling type 2 diabetes-like hyperglycemia in C. elegans on a microdevice.

      Guoli Zhu, Fangchao Yin, Li Wang, Wenbo Wei, Lei Jiang and Jianhua Qin

      Integrative Biology, 2016, 8(1), 30-38

    • Bezafibrate–mizoribine interaction: Involvement of organic anion transporters OAT1 and OAT3 in rats.

      Yuan Feng , Changyuan Wang, Qi Liu, Qiang Meng, Xiaokui Huo, Zhihao Liu, Pengyuan Sun,Xiaobo Yang, Huijun Sun, Jianhua Qin, Kexin Liu

      European Journal of Pharmaceutical Sciences, 2016, 81,119–128

    • Human induced pluripotent stem cell-derived beating cardiac tissues on paper.

      Li Wang, Cong Xu, Yujuan Zhu, Yue Yu, Ning Sun, Xiaoqing Zhang, Ke Feng and Jianhua Qin

      Lab Chip, 2015,15, 4283-4290(Cover image)

    • Controlled H2O2 release via long-lived electron-hole separation mediated to induce tumor cell apoptosis.

      Cong Wang, Xinghua Gao, Yibo Gao, Wenbin Cao, Jinxuan Tian, Xiaoxiao Wu, Ziran Ye, Xiping Zeng, Jun Wan, Jinbo Wu, Zhengyu Fang, BingPu Zhou, Jianhua Qin and Weijia Wen

      Journal of Materials Chemistry B, 2015,3, 8115-8122

    • Progress of Microfluidics-based Immunoassays in Detection of Cardiac Markers.

      SU Wentao, FENG Ke, QIN Jianhua

      Chinese Journal of Analytical Chemistry, 2015(10),1490-1498

    • Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues.

      Xu Zhang, Zhaoxu Meng, Jingyun Ma, Yang Shi, Hui Xu, Simon Lykkemark and Jianhua Qin

      Small, 2015, 11(30),3666-3675

    • Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy.

      Hui Xu, Shervin Rahimpour, Cody L. Nesvick, Xu Zhang, Jingyun Ma, Min Zhang, Ge Zhang, Li Wang, Chunzhang Yang, Christopher S. Hong, Anand V. Germanwala, J. Bradley Elder, Abhik Ray-Chaudhury, Yu Yao, Mark R. Gilbert, Russell R. Lonser, John D. Heiss, Roscoe O. Brady, Ying Mao, Jianhua Qin and Zhengping Zhuang

      Oncotarget, 2015,6(14),11882-11893

    • Hypoxia Combined with Spheroid Culture Improves Cartilage Specific Function in Chondrocytes.

      Yang Shi, Jingyun Ma, Xu Zhang, Hongjing Li, Lei Jiang and Jianhua Qin

      Integrative Biology, 2015, 7, 289 – 297(Cover image)

    • A Droplet Microchip with Substance Exchange Capability for the Developmental Study of C. elegans.

      Hui Wen, Yue Yu, Guoli Zhu, Lei Jiang and Jianhua Qin

      Lab on a Chip, 2015, 15(8),1905-1911

    • Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-a-induced VCAM-1, ICAM-1and EL expression via the NF-kB pathway.

      Shan Wu, Hui Xu, Jinyong Peng, Changyuan Wang, Yue Jin, Kexin Liu, Huijun Sun, Jianhua Qin

      Biochimie, 2015, 110, 62-72

    • Regulating cell behaviors on micropillar topographies affected by interfacial energy.

      Xinghua Gao, Yeung Yeung Chau, Jiao Xie, Jun Wan, Yanxiao Ren, Jianhua Qin and Weijia Wen

      RSC Adv., 2015, 5, 22916-22922

    • Regulation of cell migration and osteogenic differentiation in mesenchymal stem cells under extremely low fluidic shear stress.

      Xinghua Gao, Xu Zhang, Hui Xu, Bingpu Zhou, Weijia Wen, and Jianhua Qin

      Biomicrofluidics, 2014,8, 052008

    • Microfluidic platform towards point-of-care diagnostics in infectious diseases.

      Wentao Su, Xinghua Gao, Lei Jiang and Jianhua Qin

      Journal of Chromatography A, 2015, 13-26

    • Flexible Fabrication of Biomimetic Bamboo-like Hybrid Microfibers.

      Yu Y, Wen H, Ma JY, Lykkemark S, Xu H, Qin JH

      Advanced Materials, 2014, 26(16): 2494–2499 (Cover image)

    • Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip.

      Wen H, Gao XH, Qin JH

      Integrative Biology, 2014, 6 (1): 35–43 (Cover image)

    • Induction of epithelial-to-mesenchymal transition in proximal tubular epithelial cells on microfluidic devices.

      Zhou MY, Ma HP, Lin HL, Qin JH

      Biomaterials, 2014, 35: 1390-1401

    • A simple microfluidic strategy for cell migration assay in an in-vitro wound healing model.

      Zhang M, Li HJ, Ma HP, Qin JH

      Wound Repair and Regeneration, 2013, 21(6): 897–903

    • Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles.

      Wang X, Li SB, Wang LM, Yi X, Hui YS, Qin JH, Wen WJ

      Journal of Nanomaterials, 2013, ID 864584

    • A high efficiency microfluidic-based photocatalytic microreactor using electrospun nanofibrous TiO2 as photocatalyst.

      Meng ZX, Zhang X, Qin JH

      Nanoscale, 2013, 5, 4687-4690

    • Facile Synthesis of Biomimetic Honeycomb Material with Biological Functionality.

      Ma JY, Hui YS, Zhang M, Yu Y, Wen WJ, Qin JH

      Small, 2013, 9(4), 497–503 (Cover image)

    • An integrated microfluidic device for characterizing chondrocyte metabolism in response to distinct levels of fluid flow stimulus.

      Zhong WL, Ma HP, Wang SY, Gao XH, Zhang WG, Qin JH

      Microfluidics and Nanofluidics,2013, 15(6): 763-773

    • High throughput generation and trapping of individual agarose microgel using microfluidic approach.

      Shi Y, Gao XH, Chen LQ, Zhang M, Ma JY, Zhang XX, Qin JH

      Microfluidics and Nanofluidics,2013, 4, 467-474

    • Biomimetic tumor microenvironment on a microfluidic platform.

      Ma HP, Xu H, Qin JH

      Biomicrofluidics,2013, 7, 011501

    • Simple localization of nanofiber scaffolds via SU-8 photoresist and their use for parallel 3D cellular assays.

      Jiang L, Zhang M, Li JX, Wen WJ, Qin JH.

      Advanced Materials 2012, 24(16), 2191-2195

    • Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices.

      Ma HP, Zhang M, Qin JH.

      Integrative Biology 2012, 4(5):522-530.

    • A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime.

      Zhang Q, Liu TJ, Qin JH.

      Lab on a chip 2012, 12:2837-2842.

    • Multiparameter evaluation of the longevity in C. elegans under stress using an integrated microfluidic device.

      Wen H, Shi WW, Qin JH.

      Biomed Microdevices 2012, 14(4):721-728.

    • Microalgal motility measurement microfluidic chip for toxicity assessment of heavy metals.

      Zheng GX, Wang YH, Qin JH

      Analytical and Bioanalytical Chemistry,2012, 404(10), 3061-3069

    • Flexible generation of gradient electrospinning nanofibers using a microfluidic assisted approach.

      Zhang X, Gao XH, Jiang L, and Qin JH.

      Langmuir 2012, 28(26):10026-10032.

    • Analysis of Caenorhabditis elegans in microfluidic devices.

      Wen H, Qin JH.

      SCIENCE CHINA (Chemistry) 2012, 55(4), 484-493

    • Fast detection of genetic information by an optimized PCR in an interchangeable chip.

      Wu JB, Kodzius R, Xiao K, Qin JH, Wen WJ.

      Biomedical Microdevices 2012, 14(1):179-186.

    • Synthesis of shape-controlled particles based on synergistic effect of geometry confinement, double emulsion template, and polymerization quenching.

      Zhang QQ, Lin BC, Qin JH.

      Microfluidics and Nanofluidics 2012, 12(1-4):33-39.

    • Nanofiber-modified surface directed cell migration and orientation in microsystem.

      Zhang X, Gao X, Jiang L, Zhang XL, Qin JH.

      Biomicrofluidics 2011, 5(3) :032007

    • Patterning cell using Si-stencil for high-throughput assay.

      Wu JB, Zhang MY, Chen LQ, Yu Vivian, Wong Joseph Tin-Yum, Zhang XX, Qin JH, Wen WJ.

      RSC Advances 2011, 1(5):746-750.

    • Controllable synthesis of anisotropic elongated particles using microvalve actuated microfluidic approach.

      Zhang QQ, Zeng SJ, Lin BC, Qin JH.

      Journal of Materials Chemistry 2011, 21(8):2466-2469.

    • Microdroplet-based universal logic gates by electrorheological fluid.

      Zhang M, Wang L, Wang X, Wu J, Li J, Gong X, Qin J, Li W, Wen WJ

      Soft Matter 2011, 7(16):7493-7497.

    • A simple elastic membrane-based microfluidic chip for the proliferation and differentiation of mesenchymal stem cells (MSCs) under tensile stress.

      Gao XH, Zhang X, Tong HY, Lin BC , Qin JH

      Electrophoresis 2011, 32(23):3431-3436.

    • Microfluidic Platform for the Study of Caenorhabditis elegans.

      Shi WW, Wen H, Lin BC, Qin JH.

      Topics in current chemistry 2011, 304:323-338.

    • Patterned Paper as a Low-Cost, Flexible Substrate for Rapid Prototyping of PDMS Microdevices via "Liquid Molding".

      Lu Y, Lin BC, Qin JH.

      Analytical Chemistry 2011, 83(5):1830-1835.

    • Electrical Control of Individual Droplet Breaking and Droplet Contents Extraction.

      Zeng SJ, Pan XY, Zhang QQ, Lin BC, Qin JH.

      Analytical Chemistry 2011, 83(6):2083-2089.

    • Droplet microfluidics for characterizing the neurotoxin-induced responses in individual Caenorhabditis elegans.

      Shi WW, Wen H, Lu Y, Shi Y, Lin BC, Qin JH.

      Lab on a Chip 2010, 10(21).2855-2863.

    • Wax-bonding 3D microfluidic chips.

      Gong XQ, Yi X, Xiao K, Li SB, Kodzius R, Qin JH, Wen WJ.

      Lab on a Chip 2010, 10(19).2622-2627.

    • Microvalve and micropump controlled shuttle flow microfluidic device for rapid DNA hybridization.

      Huang SQ, Li CY, Lin B, Qin J.

      Lab on a Chip 2010, 10(21).2925-2931.

    • The Effects of Insulin-Like Growth Factor-1 and Basic Fibroblast Growth Factor on the Proliferation of Chondrocytes Embedded in the Collagen Gel Using an Integrated Microfluidic Device.

      Li YC, Qin JH, Lin BC, Zhang WG.

      Methods 2010, 16(6).1267-1275.

    • Embellishment of microfluidic devices via femtosecond laser micronanofabrication for chip functionalization.

      Wang J, He Y, Xia H, Niu L-G, Zhang R, Chen QD, Zhang YL, Li YF, Zeng SJ, Qin JH,Lin BC, Sun HB.

      Lab on a Chip 2010, 10(15):1993-1996.

    • Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device.

      Liu TJ, Lin BC, Qin JH.

      Lab on a Chip 2010, 10(13).1671-1677.

    • Characterization of the interaction between fibroblasts and tumor cells on a microfluidic co-culture device.

      Ma HP, Liu TJ, Qin JH, Lin B.

      Electrophoresis 2010, 31(10).1599-1605.

    • A simple photolithography method for microfluidic device fabrication using sunlight as UV source.

      Ma JY, Jiang L, Pan XY, Ma HP, Lin BC, Qin JH.

      Microfluidics and Nanofluidics 2010, 9(6).1247-1252

    • A microfluidic device integrated with multichamber polymerase chain reaction and multichannel separation for genetic analysis.

      Pan X, Jiang L, Liu K, Lin BC, Qin JH.

      Analytica Chimica Acta 2010, 674(1).110-115.

    • Microfluidic devices for characterizing the agonist of formyl peptide receptor in RBL-FPR cells.

      Ye NN, Wang MW, Qin JH, Lin BC.

      Biomedical Microdevices 2010, 12(3).513-521.

    • Fabrication and Characterization of Paper-Based Microfluidics Prepared in Nitrocellulose Membrane By Wax Printing.

      Lu Y, Shi WW, Qin JH, Lin BC.

      Analytical Chemistry 2010, 82(1).329-335.

    • Microvalves actuated sandwich immunoassay on an integrated microfluidic system.

      Gao XH, Jiang L, Su XO, Qin JH, Lin BC.

      Electrophoresis 2009, 30(14).2481-2487.

    • An Immobilized Lipase Microfluidic Reactor for Enantioselective Hydrolysis of Ester.

      Gao Y, Zhong RT, Qin JH, Lin BC.

      Chemistry Letters 2009, 38(3).262-263.

    • Integrated microfluidic immunoassay for the rapid determination of clenbuterol.

      Kong J, Jiang L, Su X, Qin J, Du Y, Lin B.

      Lab on a Chip 2009, 9(11).1541-1547.

    • Rapid nanoliter DNA hybridization based on reciprocating flow on a compact disk microfluidic device.

      Li CY, Dong XL, Qin JH, Lin BC.

      Analytica Chimica Acta 2009, 640(1-2).93-99.

    • Rapid discrimination of single-nucleotide mismatches based on reciprocating flow on a compact disc microfluidic device.

      Li CY, Li HJ, Qin JH, Lin BC.

      Electrophoresis 2009, 30(24).4270-4276

    • A microfluidic device for characterizing the invasion of cancer cells in 3-D matrix.

      Liu TJ, Li CY, Li H, Zeng SJ, Qin H, Lin BC.

      Electrophoresis 2009, 30(24).4285-4291.

    • A facile "liquid-molding'' method to fabricate PDMS microdevices with 3-dimensional channel topography.

      Liu X, Wang Q, Qin JH, Lin BC.

      Lab on a Chip 2009, 9(9).1200-1205.

    • Rapid prototyping of paper-based microfluidics with wax for low-cost, portable bioassay.

      Lu Y, Shi WW, Jiang L, Qin JH, Lin BC.

      Electrophoresis 2009, 30(9).1497-1500.

    • Low cost, portable detection of gold nanoparticle-labeled microfluidic immunoassay with camera cell phone.

      Lu Y, Shi WW, Qin JH, Lin BC.

      Electrophoresis 2009, 30(4).579-582.

    • Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device.

      Ma B, Zhang GH, Qin JH, Lin BC.

      Lab on a Chip 2009, 9(2).232-238.

    • A programmable microvalve-based microfluidic array for characterization of neurotoxin-induced responses of individual C. elegans.

      Ma H, Jiang L, Shi WW, Qin JH, Lin BC.

      Biomicrofluidics 2009, 3(4). 044114

    • A splicing model-based DNA-computing approach on microfluidic chip.

      Xie H, Li BW, Qin JH, Huang ZD, Zhu YS, Lin BC.

      Electrophoresis 2009, 30(20).3514-3518.

    • Microvalve-actuated precise control of individual droplets in microfluidic devices.

      Zeng SJ, Li BW, Su XO, Qin JH, Lin BC.

      Lab on a Chip 2009, 9(10).1340-1343.

    • Microfluidic droplet trapping array as nanoliter reactors for gas-liquid chemical reaction.

      Zhang QQ, Zeng SJ, Qin JH, Lin BC.

      Electrophoresis 2009, 30(18).3181-3188.

    • A microfluidic DNA computing processor for gene expression analysis and gene drug synthesis.

      Zhang Y, Yu H, Qin JH, Lin BC.

      Biomicrofluidics 2009, 3(4). 044105

    • Simply and reliably integrating micro heaters/sensors in a monolithic PCR-CE microfluidic genetic analysis system.

      Zhong R, Pan X, Jiang L, Dai Z, Qin J, Lin B.

      Electrophoresis 2009, 30(8).1297-1305.

    • Microfluidic device for integrated restriction digestion reaction and resulting DNA fragment analysis.

      Xie H, Li BW, Zhong RT, Qin JH, Zhu YS, Lin BC.

      Electrophoresis 2008, 29(24).4956-4963.

    • Simple, fast and high-throughput single-cell analysis on PDMS microfluidic chips.

      Yu L, Huang H, Dong X, Wu DP, Qin JH, Lin BC.

      Electrophoresis 2008, 29(24).5055-5060.

    • Droplet-based microfluidic system for individual Caenorhabditis elegans assay.

      Shi WW, Qin JH, Ye NN, Lin BC.

      Lab on a Chip 2008, 8(9).1432-1435.

    • Electrophoretic separations on microfluidic chips.

      Wu DP, Qin JH, Lin BC.

      Journal of Chromatography A 2008, 1184(1-2).542-559.

    • Microfluidic chip-based cell electrophoresis with multipoint laser-induced fluorescence detection system.

      Yu LF, Shen Z, Mo J, Dong XL, Qin JH, Lin BC.

      Electrophoresis 2007, 28(24).4741-4747.

    • Fabrication of two-weir structure-based packed columns for on-chip solid-phase extraction of DNA.

      Zhong RT, Liu DY, Yu LF, Ye NN, Dai ZP, Oin JH, Lin BC.

      Electrophoresis 2007, 28(16).2920-2926.

    • Quantitative evaluation of the interaction between netropsin and double stranded oligodeoxynucleotides by microfabricated capillary array electrophoresis.

      Shen Z, Liu XJ, Zhou XM, Liang AY, Wu DY, Yu LF, Dai ZP, Qin JH, Lin BC.

      Journal of Separation Science 2007, 30(10).1544-1548.

    • Characterizing doxorubicin-induced apoptosis in HepG2 cells using an integrated microfluidic device.

      Ye NN, Qin JH, Shi WW, Lin BC.

      Electrophoresis 2007, 28(7).1146-1153.

    • Development of a universal serial bus-powered mini-high-voltage power supply for microchip electrophoresis.

      Jiang L, Jiang X, Lu Y, Dai Z, Xie M, Qin JH, Lin BC.

      Electrophoresis 2007, 28(8).1259-1264.

    • Self-assembled epoxy-modified polymer coating on a poly(dimethylsiloxane) microchip for EOF inhibition and biopolymers separation.

      Wu DP, Qin JH, Lin BC.

      Lab on a Chip 2007, 7(11).1490-1496.

    • Cell-based high content screening using an integrated microfluidic device.

      Ye NN, Qin JH, Shi WW, Liu X, Lin BC.

      Lab on a Chip 2007, 7(12).1696-1704.

    • Integrated multilayer microfluidic device with a nanoporous membrane interconnect for online coupling of solid-phase extraction to microchip electrophoresis.

      Long ZC, Shen Z, Wu DP, Qin JH, Lin BC.

      Lab on a Chip 2007, 7(12).1819-1824.

    • Maze exploration and learning in C. elegans

      Qin JH, and A.R. Wheeler

      Lab on a Chip 2007, 7, 186-192

    • Integration of nanoporous membranes for sample filtration/preconcentration in microchip electrophoresis.

      Long ZC, Liu DY, Ye NN, Qin JH, Lin BC.

      Electrophoresis 2006, 27(24).4927-4934.

    • Double-cross hydrostatic pressure sample injection for chip CE. Variable sample plug volume and minimum number of electrodes.

      Luo Y, Wu DP, Zeng SJ, Gai HW, Long ZC, Shen Z, Dai ZP, Qin JH, Lin BC.

      Analytical Chemistry 2006, 78(17).6074-6080.

    • Parallel analysis of biomolecules on a microfabricated capillary array chip.

      Shen Z, Liu XJ, Long ZC, Liu DY, Ye NN, Qin JH, Dai ZP, Lin BC.

      Electrophoresis 2006, 27(5-6).1084-1092.

    • Grafting epoxy-modified hydrophilic polymers onto poly(dimethylsiloxane) microfluidic chip to resist nonspecific protein adsorption.

      Wu DP, Zhao BX, Dai ZP, Qin JH, Lin BC.

      Lab on a Chip 2006, 6(7).942-947.

    • Mini-electrochemical detector for microchip electrophoresis.

      Jiang L, Lu Y, Dai ZP, Xie MH, Lin BC.

      Lab on a Chip 2005, 5(9).930-934.

    • Genotyping the-6A/G functional polymorphism in the core promoter region of angiotensinogen gene by microchip electrophoresis.

      Qin JH, Liu ZY, Wu DP, Zhu N, Zhou XM, Fung YS, Lin BC.

      Electrophoresis 2005, 26(1).219-224.

    • Microfluidic devices for the analysis of apoptosis.

      Qin JH, Ye NN, Liu X, Lin BC.

      Electrophoresis 2005, 26(19).3780-3788.

    • Simultaneous and ultrarapid determination of reactive oxygen species and reduced glutathione in apoptotic leukemia cells by microchip electrophoresis.

      Qin JH, Ye NN, Yu LF, Liu DY, Fung YS, Wang W, Ma XJ, Lin BC.

      Electrophoresis 2005, 26(6).1155-1162.

     

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●2020-09-19王亚清等利用人肝类器官芯片体系用于非酒精性脂肪肝病的研究工作发表在ACS Biomaterials Science & Engineering. 2020, DOI: 10.1021/acsbiomaterials.0c00682。

●2020-08-15王亚清等采用一步法制备复合水凝胶微囊用于hiPSCs诱导肝类器官的研究工作发表在Biomaterials Science. 2020, DOI: 10.1039/D0BM01085E。

●2020-07-13朱玉娟等开展工程化构建干细胞来源羊膜组织与发育研究工作发表在Lab on a Chip. 2020, DOI: 10.1039/D0LC00268B。

●2020-07-13崔康莉等利用脑类器官芯片研究生命早期药物暴露对神经发育影响的工作发表在Microsystems & Nanoengineering. 2020, 6, 49。

●2020-04-25王慧等利用双水相液滴微流控体系制备多腔水凝胶微囊载体的工作发表在Adv. Mater. Technol. 2020, 2000045。

●2020-04-13刘海涛、王亚清等基于双水相液滴微流控体系制备杂合水凝胶微囊用于胰岛类器官研究的工作发表在Advanced Science. 2020, 1903739。

●2019-10-31陈雯雯等利用新型微流控装置分离、检测乳腺癌病人血液中外泌体的工作发表在Biomicrofluidics. 2019, 13, 054113。

●2019-07-08 我组受邀在国际刊物 Advanced Materials 上发表基于水凝胶材料的类器官与器官芯片研究综述 (Advanced Materials, 2019, DOI: 10.1002/adma.201902042)。

●2019-07-04 我组在国际刊物Trends in Analytical Chemistry上发表有关无标记外泌体分离和分析策略的邀请综述。 (Trends in Analytical Chemistry. 2019, 118, 686-698)。

●2019-02-05陶婷婷等利用器官芯片技术构建干细胞来源胰岛类器官工作发表在Lab on a Chip, 2019, DOI: 10.1039/C8LC01298A。

●2019-01-08 我组王慧博士等利用液滴微流控技术“一步法”制备核壳状水凝胶微球的工作发表在Adv. Mater. Technol, 2019, 1800632。

●2018-10-30王亚清等有关工程化构建人多能干细胞来源肝脏类器官及药物评价的研究工作发表在Lab on a Chip, 2018, DOI: 10.1039/c8lc00869h

●2018-09-25我组刘海涛等利用微流控技术制备双水相生物微载体的研究工作发表在Small,2018, 14(36):1801095

●2018-09-21大连化物所器官芯片研究工作持续引起国际关注

●2018-09-12秦建华入选英国皇家化学会“卓越研究——百位化学界女性”

●2018-08-22我组朱玉娟博士等利用器官芯片技术研究胎盘界面感染细菌过敏的工作发表在ACS Biomaterials Science & Engineering(2018, DOI:10.1021/acsbiomaterials.8b00653),并被美国每日科学(Science Daily)亮点报道。

●2018-08-22我组张敏等利用动态三维肺芯片模型开展纳米颗粒毒性评价研究工作发表在Toxicology Research.(2018,DOI: 10.1039/C8TX00156A)。

●2018-07-09中国科学院上海神经科学研究所陈跃军教授来我组实验室访问并做题为“Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson's Disease”的学术报告。

●2018-06-06香港科技大学唐本忠院士受邀来所做第八期所庆报告

●2018-03-26我组尹方超等利用类脑器官芯片研究镉暴露对胎儿脑发育影响工作作为封面文章发表在ACS Biomaterials Science & Engineering。

●2018-02-06我组王亚清等人脑类器官芯片评价妊娠期尼古丁暴露对胎儿脑损伤的研究工作被Lab on a Chip杂志接受。

●2018-01-19美国国家工程院院士Kam W. Leong来访参观实验室,并做题为“Bioengineering of Direct Cell Reprogramming”的学术报告。

●2017-12-26秦建华受邀出席香山科学会议并做“人体器官芯片”主题报告

●2017-09-05祝贺李中玉同学顺利完成博士研究生毕业答辩。

●2017-07-14我组王丽荣获中国毒理学会联合利华毒理学替代法创新奖

●2017-06-13秦建华研究员受邀出席诺贝尔微流控主题高端论坛

●2017-06-01我组李中玉同学等肠肾芯片药物吸收相关肾毒性评价的研究工作发表在Biomicrofluidics杂志(DOI:http://dx.doi.org/10.1063/1.4984768)。

●2017-05-22我组王丽等利用器官芯片技术构建糖尿病肾病模型的研究工作发表在Lab on a Chip杂志(2017,17(10):1749-1760)。

●2017-04-07我组李中玉同学等利用构建的肾脏器官芯片评估镉致肾毒性的研究工作发表在Toxicology Research杂志(2017, 6, 372-380)。

●2017-01-09祝贺许慧同学顺利完成博士研究生毕业答辩。

●2016-12-05我组利用器官芯片技术仿生构建三维动态血脑屏障模型取得新进展。

●2016-11-17祝贺我组于跃同学获得2016年卢嘉锡优秀研究生奖。

●2016-10-10我组许慧等血脑屏障器官芯片及脑肿瘤研究工作发表在Scientific Reports(DOI 10.1038/srep36670)。

●2016-08-25我组李中玉等基于多器官芯片的肝代谢依赖性抗肿瘤药物评价工作取得新进展,研究成果作为封面文章发表在Integrative Biology,2016,8,1022-1029。

●2016-08-19欢迎新同学刘海涛和王慧加入课题组。

●2016-07-05 ChemSusChem杂志主编Guido Kemeling博士和Small杂志主编Jose Oliveira博士来访参观实验室,并与实验室成员进行了深入交流。

●2016-07-04欢迎于浩老师加入课题组。

●2016-07-04国家纳米科学中心陈春英研究员应邀来访,并做了题为“针对肿瘤干细胞治疗的纳米药物协同治疗策略”的学术报告,并与工作人员和学生进行了深入交流。

●2016-07-02北京大学黄建滨教授来访参观实验室,并做了题为“两亲分子与环糊精的多尺度自组装”的学术报告,并与实验室成员进行了深入交流。

●2016-06-07中国科学院微生物研究所朱宝利研究员应邀来访,并做了题为“人类肠道微生物组与精准医学”的学术报告,并与实验室成员进行了深入交流。

●2016-05-31我组于跃等在利用微流控技术进行可控制备多腔纤维生物材料研究方面取得新进展,研究工作发表在Advanced Materials(DOI 10.1002/adma.201601504)。

●2016-05-25美国哈佛大学著名教授David A. Weitz来访参观实验室,并做了题为“Droplet-based Microfluidics for Precision Medicine”的学术报告,并与实验室成员进行了深入交流。

●2016-05-02王丽等研究成果“Human induced pluripotent stem cells derived endothelial cells mimicking vascular inflammatory response under flow”发表在Biomicrofluidics杂志。

●2016-04-25博士生王亚清、郭雅琼参加2016年4月20-22日在韩国首尔举行的第八届MMB会议,并都以墙报形式展示我们的研究工作。

●2016-04-18欢迎刘慧、窦颖、于李、崔鹏丽、谢奕等加入课题组。

●2015-10-30博士生徐聪、李中玉参加2015年10月25-29日在韩国庆州举行的第十九届MicroTAS会议,并分别做口头报告和墙报展示。

●2015-10-21祝贺于跃同学获得2015年度研究生国家奖学金。

●2015-09-18王丽等研究成果“Human induced pluripotent stem cell-derived beating cardiac tissues on paper”作为封面文章发表在Lab chip。

●2015-05-20祝贺于跃同学获得2015年度"延长石油优秀博士生奖学金"。

●2015-05-18张旭等研究成果“Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues”被Small杂志接收,并被MaterialsViewsChina进行亮点报道。

●2015-03-12欢迎李纯,冯可,包暄文等加入课题组。

●2015-03-11许慧等研究成果“Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy”被Oncotarget接收。

●2015-03-10石杨等研究成果“Hypoxia Combined with Spheroid Culture Improves Cartilage Specific Function in Chondrocytes”作为封面发表在Integrative Biology。

●2015-02-13温慧等研究成果”A Droplet Microchip with Substance Exchange Capability for the Developmental Study of C. elegans”发表在Lab on a chip。

●2014-12-15祝贺秦建华研究员当选为英国皇家化学学会会士(Fellow of the Royal Society of Chemistry)。http://www.dicp.cas.cn/xwdt/ttxw/201412/t20141215_5211061.html

●2014-08-03由中国科学院大连化学物理研究所与英国皇家化学会Lab on a Chip杂志共同主办的“The Lab on a Chip Industry Workshop–Microfluidic Applications”会议圆满闭幕。

●2014-05-20由我组与Lab on a Chip杂志共同主办的“The Lab on a Chip Industry Workshop–Microfluidic Applications”会议将于2014年8月2-3日在大连举行,投稿截止日期2014年7月1日。详情请见http://www.locchina.com

●2014-03-30第十八届MicroTAS会议(The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences)将于2014年10月26-30日在美国举行,投稿截止日期2014年4月15日。详情请见http://www.microtas2014.org

●2013-12-18于跃同学等有关仿生合成竹节结构纤维材料研究工作被Advanced Materials杂志接收

●2013-11-01博士生于跃、张旭参加10月27-31日在德国弗莱堡举行的第十七届MicroTAS会议,并分别以口头报告、墙报的形式展示了我们研究工作

●2013-10-27温慧同学等有关线虫衰老研究工作作为封面文章在Integrative Biology杂志发表

●2013-09-01欢迎李中玉、Simon Lykkemark (Denmark)、朱国丽、陶婷婷、李盈义、盛坤、付玥玥等新同学入组

●2013-07-20祝贺马静云同学获得2013年度"延长石油优秀博士生奖学金"

●2013-04-02我组孟昭旭博士在Nanoscale杂志发表关于二氧化钛电纺丝纤维为催化剂的光催化微反应芯片研究

●2013-02-26我组马静云同学等微流控技术仿生合成蜂巢状生物功能材料相关工作作为封面文章在Small杂志发表,同时,该工作被Lab on a chip杂志Noteworthy Chemistry(ACS)及MaterialsViewsChina网站进行亮点报道

●2013-02-13我组石杨同学等微流控芯片上高通量单个微凝胶操控研究被Microfluidics and Nanofluidics杂志接收

●2013-01-08我组马慧朋同学在Biomicrofluidics杂志发表微流控芯片肿瘤微环境研究进展的综述文章

●2012-11-08德国佛雷堡大学Roland Zengerle教授来访并与实验室成员进行深入广泛的学术交流

●2012-08-27香港大学黄建东教授来访参观实验室,并做题为"合成生物学方法编码细胞的时空分布"的报告

●2012-08-03祝贺高兴华同学获得2012年度"DICP-Corning奖学金

●2012-07-29祝贺马慧朋同学获得2012年度"延长石油优秀博士生奖学金"

●2012-07-23欢迎苏文涛博士加入我组进行博士后工作

●2012-07-12我组秦建华研究员受邀担任国际刊物Lab on a Chip副主编。详见

●2012-07-01祝贺郑国侠顺利通过博士后出站答辩

●2012-05-30由我组主办的第三届国际微纳流控学进展学术会议(AMN2012)隆重闭幕

●2012-05-22祝贺孟昭旭博士获中国博士后科学基金

●2012-04-10我组姜雷等人工作在微纳流控细胞学研究取得新进展

●2012-04-09我组温慧同学微流控芯片上线虫衰老研究工作发表