欢迎访问中科院大连化学物理研究所 生物微流控系统研究组!

Introduction

Our group is highly interdisplinary team involving the researchers from chemistry, biology, materials, medicine, and engineering fields. The current research interests lie in the interface of microfluidics, bioengineering, biomaterials, medicine and stem cell biology. We are focusing on the development of bioinspired living model systems and biomedical devices to understand tissue/organ development, and study various physio-pathological processes of human body that may lead to the design of new diagnostic schemes and therapeutic strategies. 【More】

Group Leader

Dr.Jianhua Qin is currently a chair professor in Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS). She has been appointed as the group leader in DICP since 2006,and the director of Microfluidics Research Center since 2009. Dr. Qin is an adjunctive professor at CAS Center for Excellence in Brain Science and Intelligence Technology, and Institute for Stem Cell and Regeneration at CAS. She has received Ph.D i... 【More】

PublicationMore>>

    • Fluidic Flow Enhances the Differentiation of Placental Trophoblast-Like 3D Tissue from hiPSCs in a Perfused Macrofluidic Device

      Pengwei Deng,Kangli Cui,Yang Shi,Yujuan Zhu,Yaqing Wang,Xiaoguang Shao,Jianhua Qin

      Frontiers in Bioengineering and Biotechnology. 2022, DOI: 10.3389/fbioe.2022.907104

    • Human organoids and organs-on-chips for addressing COVID-19 challenges

      Yaqing Wang,Peng Wang,Jianhua Qin

      Advanced Science. 2022, DOI: 10.1002/advs.202105187

    • Microengineered multi-organoid system from hiPSCs to recapitulate human liver-islet axis in normal and type 2 diabetes

      Tingting Tao,Pengwei Deng,Yaqing ...

Latest news More>>

●2022-06-30 Pengwei Deng and co-author's  work entitled"Fluidic Flow Enhances the Differentiation of Placental Trophoblast-Like 3D Tissue from hiPSCs in a Perfused Macrofluidic Device"has been published in Frontiers in Bioengineering and Biotechnology.2022, DOI: 10.3389/fbioe.2022.907104

●2022-04-16 Congratulations to Wenwen Chen for successfully completing her doctoral defense.

●2022-03-05 Congratulations to Kangli Cui for successfully completing her doctoral defense.

●2022-02-03 Yaqing Wang and co-author's  review entitled"Human organoids and organs-on-chips for addressing COVID-19 challengess"has been published in Advanced Science.2022, DOI: 10.1002/advs.202105187

●2022-01-08 Congratulations to Tingting Tao for successfully completing her doctoral defense.

●2021-11-25 Tingting Tao and co-author's  work entitled"Microengineered multi-organoid system from hiPSCs to recapitulate human liver-islet axis in normal and type 2 diabetes"has been published in Advanced Science.2021, DOI: 10.1002/advs.202103495

●2021-11-23 Kangli Cui and co-author's  work entitled"Establishment of Trophoblast-Like Tissue Model from Human Pluripotent Stem Cells in Three-Dimensional Culture System"has been published in Advanced Science.2021, DOI: 10.1002/advs.202100031

●2021-11-09 Congratulations to Hui Wang in our group for winning the 2021 National Scholarship for Postgraduates.

●2021-11-05 Congratulations to Hui Wang for successfully completing her doctoral defense.

●2021-10-27 Wenwen Chen and co-author's  work entitled"A Protable Device for Simple Exosome Separation from Biological Samples"has been published in Micromachines.2021, DOI: 10.3390/mi12101182

●2021-08-30 Congratulations to Haitao Liu for successfully completing her doctoral defense.

●2021-08-29 Yaqing Wang and co-author's  review entitled"Microfluidic Organs-on-a-Chip for Modeling Human Infectious Diseases"has been published in Account of Chemical Reserch.2021, DOI: 10.1021/acs.accounts.1c00411

●2021-06-22 Congratulations to Wang Hui of our group who won the third prize of Bohai Chemical Industry in 2021.

●2021-05-06 Congratulations to Yaqiong Guo for successfully completing her doctoral defense.

●2021-03-12 Wenwen Chen and co-author's  work entitled "Simple and fast isolation of circulating exosomes with a chitosan modified shuttle flow microchip for breast cancer diagnosis" has been published in Lab on a Chip. 2021, DOI: 10.1039/D0LC01311K.

●2021-01-27 Fan He and co-author's  work entitled "Controllable Fabrication of Composite CoreShell Capsules at a Macroscale as Organoid Biocarriers" has been published in ACS Applied Bio Materials. 2021, DOI: 10.1021/acsabm.0c01441.

●2021-01-06 Hui Wang and co-author's  work entitled "One-Step Generation of Aqueous-Droplet-Filled Hydrogel Fibers as Organoid Carriers Using an All-in-Water Microfluidic System" has been published in ACS Applied Materials & Interfaces. 2021, DOI: 10.1021/acsami.0c20434.

●2020-12-01 Yaqiong Guo and co-author's  work entitled "SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip" has been published in Science Bulletin. 2020, DOI: 10.1016/j.scib.2020.11.015.

●2020-11-28 Congratulations to Yaqing Wang for successfully completing her doctoral defense.

●2020-11-24 Fangchao Yin and co-author's  work entitled "HiPSC-derived multi-organoids on chip system for safety assessment of antidepressant drug" has been published in Lab on a Chip. 2020, DOI: 10.1039/D0LC00921K.

2020-11-17 Peng Wang and co-author's  work entitled "A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection" has been published in Cell Death and Disease. 2020, DOI: 10.1038/s41419-020-03252-9.

●2020-10-24 Min Zhang and co-author's work entitled "Biomimetic Human Disease Model of SARS-CoV-2 Induced Lung Injury and Immune Responses on Organ Chip System" has been published in Advanced Science. 2020, DOI: 10.1002/advs.202002928.

●2020-09-16 Yaqing Wang and co-author's work entitled "Modeling Human Nonalcoholic Fatty Liver Disease (NAFLD) with an Organoids-on-chip System" has been published in ACS Biomaterials Science & Engineering. 2020, DOI: 10.1021/acsbiomaterials.0c00682.

●2020-08-15 Yaqing Wang and co-author's work entitled "One-step synthesis of composite hydrogel capsules to support liver organoids generation from hiPSCs" has been published in Biomaterials Science. 2020, DOI: 10.1039/D0BM01085E.

●2020-07-13 Yujuan Zhu and co-author's work entitled "Amnion-on-a-chip: modeling human amniotic development in mid-gestation from pluripotent stem cells" has been published in Lab on a Chip. 2020, DOI: 10.1039/D0LC00268B.

●2020-07-13 Kangli Cui and co-author's work entitled "Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model" has been published in Microsystems & Nanoengineering. 2020, 6, 49.

●2020-04-25 Hui Wang and co-author's work entitled "Flexible Generation of Multi-Aqueous Core Hydrogel Capsules Using Microfluidic Aqueous Two-Phase System" has been published in Advanced Materials Technologies, 2020, 5, 2000045.

●2020-04-13 Haitao Liu and co-author's work entitled "A Droplet Microfluidic System to Fabricate Hybrid Capsules Enabling Stem Cell Organoid Engineering" has been published in Advanced Science, 2020, 7, 1903739.

●2019-10-31 Wenwen Chen and co-author's work entitled "Microfluidic device for on-chip isolation and detection of circulating exosomes in blood of breast cancer patients" has been published in Biomicrofluidics, 2019, 13, 054113.

●2019-07-08 Our invited progress report entitled " Advances in Hydrogels in Organoids and Organ-on-a-Chip " has been published in Advanced Materials, 2019, DOI: 10.1002/adma.201902042.

●2019-07-04 Our invited review entitled "Microfluidic strategies for label-free exosomes isolation and analysis" has been published in Trends in Analytical Chemistry, 2019, 118, 686-698.

●2019-07-01 Wentao Su and co-author's work entitled "Integrated Microfluidic Device for Enrichment and Identification of Circulating Tumor Cells from the Blood of Patients with Colorectal Cancer" has been published in Disease Markers. 2019, 8945974. DOI: 10.1155/2019/8945974.

● 2019-2-5 Tingting Tao and co-author's work entitled " Engineering human islet organoids from iPSCs using an organ-on-chip platform." has been published in Lab on a Chip, 2019, DOI: 10.1039/C8LC01298A.

● 2018-10-30 Yaqing Wang and co-author's work entitled " In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system." has been published inLab on a Chip, 2018, DOI: 10.1039/c8lc00869h.

● 2018-09-25 Haitao Liu and co-author's work entitled"A Microfluidic Strategy for Controllable Generation of WaterinWater Droplets as Biocompatible Microcarriers."has been published inSmall, 2018, 14(36):1801095

● 2018-09-21 The research of Organs-on-chips in DICP continues to attract international attention.

● 2018-08-22 Dr. Yujuan Zhu and co-author's work entitled "Placental Barrier-on-a-Chip: Modeling Placental Inflammatory Responses to Bacterial Infection." was recently published in the journal of ACS Biomaterials Science & Engineering (2018, DOI:10.1021/acsbiomaterials.8b00653), and highlighted byScience Daily.

● 2018-08-22 Min Zhang and co-author's work entitled“A 3D human lung-on-a-chip model for nanotoxicity testing.”was recently published in the journal of Toxicology Research(2018, DOI: 10.1039/C8TX00156A).

● 2018-07-09 Professor Yuejun Chen, the Institute of Neuroscience, Chinese Academy of Sciences, visited our group and gave a talk entitled "Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson's Disease".

● 2018-06-06Professor Benzhong Tang, the Hong Kong University of Science and Technology, visited our group and gave the DICP 70th Anniversary Lecture ().

● 2018-03-26 Fangchao Yin and co-author's work entitled " Engineering brain organoids to probe impaired neurogenesis induced by cadmium." has been published in ACS Biomaterials Science & Engineering as a front cover (2018, 4(5),1908-1915).

● 2018-02-06 Yaqing Wang and co-author's work entitled " Human brain organoid-on-a-chip to model prenatal nicotine exposure." has been published in Lab on a Chip (2018, 18(6),851-860).

● 2018-01-19Kam W. Leong, Member of the National Academy of Engineering, visited our group and gave a talk“Bioengineering of Direct Cell Reprogramming".

● 2017-12-26Professor Jianhua Qin was invited to attend the Xiangshan Science Conferences and give a keynote report on "Human Organs-on-Chips".

● 2017-09-05 Li Zhongyu completed his oral defense of Doctor's thesis. Congratulations.

● 2017-06-01 Li Zhongyu and co-author's work entitled" Drug absorption related nephrotoxicity assessment on an intestine-kidney chip." has been published in Biomicrofluidics 11, 034114 (2017); DOI:http://dx.doi.org/10.1063/1.4984768.

● 2017-05-22 Wang Li and co-author's work entitled" A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice." has been published inLab on a Chip (2017,17(10):1749-1760).

● 2017-04-07 Li Zhongyu and co-author's work entitled" Assessment of cadmium-induced nephrotoxicity using a kidney-on-a-chip device." has been published in Toxicology Research (2017, 6, 372-380).

● 2017-01-09 Xu Hui completed her oral defense of Doctor's thesis. Congratulations.

● 2016-12-05Our organ-on-chip work entitled "A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors" was published in Scientific report 2016, DOI: 10.1038/srep36670.

● 2016-11-18 Yue Yu completed his oral defense of Doctor's thesis. Congratulations.

● 2016-11-17 Ph.D candidate Yue Yu won the Lu Jiaxi outstanding graduate student award 2016. Congratulations.

● 2016-10-10 Xu Hui and co-author's work entitled "A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumor." has been accepted for publishing in Scientific Reports (DOI: 10.1038/srep36670).

● 2016-08-25 Li Zhongyu and co-author's work entitled " Assessment of metabolism-dependent drug efficacyand toxicity on a multilayer organs-on-a-chip." has been published in Integrative Biology as a front cover (2016,8,1022-1029).

● 2016-08-19 Welcome Haitao Liu and Hui Wang to join our group as new students.

● 2016-07-05 Dr Guido Kemeling, Chief editor of ChemSusChem, and Dr.Jose Oliveira, Chief editor of Small, visited our group and carried on further communication with lab members.

● 2016-07-04 Welcome Dr. Hao Yu to join our team.

● 2016-07-04 Prof. Chunying Chen was invited to visit our lab and give a talk about "The Synergistic Strategies for Treatment of Tumor Stem Cell and Nanodrugs".

● 2016-07-02 Prof. Jianbin Huang from Peking University visited our group and gave a talk titled "Multi-scale Self-assembly of Amphiphilic Molecules andCyclodextrin".

● 2016-06-07 Prof. Baoli Zhu from Institute of Microbiology visited our group and gave a talk entitled "Human Gut Microbiome and Accurate Medicine".

2016-05-31 Yu Yue and co-author's work entitled " Simple Spinning of Heterogeneous Hollow Microfibers on Chip " has been accepted for publishing in Advanced Materials (DOI 10.1002/adma.201601504).

● 2016-05-25 Prof. David A. Weitz from Harvard University visited our group and gave a talk titled " Droplet-based Microfluidics for Precision Medicine ".

● 2016-05-02 Li Wang's work-“Human induced pluripotent stem cells derived endothelial cells mimicking vascular inflammatory response under flow” was published in Biomicrofluidics.

● 2016-04-25 Ph.D students Yaqing Wang and Yaqiong Guo attended MMB 2016 held in Seoul, Korea (Apr 20-22, 2016) and gave poster presentations.

● 2016-04-18 Welcome group members Hui Liu, Ying Dou, Li Yu, Pengli Cui and Yi Xie.

● 2015-10-30 Ph.D students Cong Xu andZhongyu Li attended MicroTAS 2015 held in Gyeongju, Korea (Oct 25-29, 2015) and gave oral and poster presentations.

● 2015-10-21 Ph.D candidate Yue Yu won the national scholarship for graduate students. Congratulations!

● 2015-09-18 Li Wang's work-“Human induced pluripotent stem cell-derived beating cardiac tissues on paper” was published as a cover in Lab chip.

● 2015-05-20 Ph.D candidate Yue Yu won the Yanchang scholarship. Congratulations!

● 2015-05-18 Xu Zhang's work-"Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues" was published in Small,which was highlighted by website of MaterialsViewsChina.

● 2015-03-12 Welcome new group members Chun LiKe Feng and Xuanwen Bao.

● 2015-03-11 Hui Xu’s work-“Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy” was accepted by Oncotarget.

● 2015-03-10 Yang Shi's work-“Hypoxia Combined with Spheroid Culture Improves Cartilage Specific Function in Chondrocytes” was published as cover in Integrative Biology.

● 2015-02-13 Hui Wen's work- “A Droplet Microchip with Substance Exchange Capability for the Developmental Study of C. elegans” was published in Lab on a chip.

● 2014-12-15 Prof. Jianhua Qin was elected as the Fellow of the Royal Society of Chemistry (FRSC).http://www.dicp.ac.cn/xwzx/zhxw/201412/t20141215_4275264.html.

● 2014-08-03 The "Lab on a Chip Industry Workshop–Microfluidic Applications" co-hosted by DICP and RSC was closed successfully.http://www.dicp.cas.cn/xwzx/xshd/201408/t20140813_4184357.html

● 2014-05-20 The "Lab on a Chip Industry Workshop–Microfluidic Applications" co-hosted by DICP and RSC will be held on August, 2-3, Dalian, China. More information is available on the website:http://www.locchina.com

● 2014-03-30 The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences(MicroTAS 2014)will be held in USA, October 26-30, 2014. The abstract submission deadline is April 15, 2014.http://www.microtas2014.org

● 2013-12-18 Yue Yu's work about biomimetic synthesis of bamboo-like microfibers was accepted by Advanced Materials

● 2013-11-01 PhD students Yue Yu and Xu Zhang attended MicroTAS 2013 held in Freiburg, Germany (Oct 27-31, 2013) and gave oral and poster presentations, respectively.

● 2013-10-27 Hui Wen's work about aging worm on a chip was published as cover in Integrative Biology

● 2013-09-01 Welcome Simon Lykkemark (Denmark), Zhongyu Li, Guoli Zhu, Tingting Tao, Yingyi Li, Kun Sheng and Yueyue Fu as new students in our group

● 2013-07-20 Congratulations to Ph.D student Jingyun Ma, who won the Yanchang award

● 2012-08-03 Congratulations to Ph.D student Xinghua Gao, who won DICP-Corning prize

● 2013-04-02 Dr. Zhaoxu Meng's research on "Microfluidic-based photocatalytic microreactor using electrospun nanofibrous TiO2 as photocatalyst" was accepted in the Journal of Nanoscale

● 2013-02-26 Research on microfluidic approach to the biomimetic synthesis of a honeycomb material with biological functionality was published as back cover inSmall, which was highlighted byLab on a chip,Noteworthy Chemistry(ACS)andwebsite of MaterialsViewsChina

● 2013-02-13 Ms. Yang Shi's work about "High throughput generation and trapping of individual agarose microgel using microfluidic approach " was accepted in Microfluidics and Nanofluidics

● 2013-01-08 Ms. Huipeng Ma's review about "biomimetic tumor microenvrionment on a chip" was published in the Journal of Biomicrofluidics

● 2012-11-08 Prof. Dr. Roland Zengerle from University of Freiburg visited our group and gave a talk titled "Microfluidic Apps on Standard Lab-Instruments"

● 2012-08-27 Prof. Jiandong Huang from the University of Hongkong visited our group and gave a talk titled "synthetic patterns: sequential establishment of stripe patterns in an expanding cell population"

● 2012-08-03 Congratulations to Ph.D student Xinghua Gao, who won DICP-Corning prize

● 2012-07-29 Congratulations to Ph.D student Huipeng Ma, who won the Yanchang award

● 2012-07-23 Welcome Dr. Wentao Su to join our lab as a postdoc

● 2012-07-12 Prof. Jianhua Qin was appointed as associate editor in Lab on a Chip

2012-05-23 The 3th International Conference on Advances in Microfluidics and Nanofluidics (AMN 2012) was open

● 2012-05-22 Congratulations to Dr. Zhaoxu Meng, who received the postdoc scholarship

2012-04-10 Dr. Jiang et,al. have made new progress in the micro-nanofluidic cytology

● 2012-04-10 Dr. Jiang's work about "Localized Nanofibers for Cellular Assay" was published in Advanced Materials

● 2012-04-09 Ms. Hui Wen's work about "The Study of Longevity of C.elegans on a Chip" was published in Biomedical Microdevice