欢迎访问中科院大连化学物理研究所 器官芯片与生物医学研究组!


●2024-09-12 Rongkai Cao and co-author's  work entitled"Assessment of nanotoxicity in a human placenta-on-a-chip from trophoblast stem cells"has been published in Ecotoxicology and Environmental Safety.2024, DOI: 10.1016/j.ecoenv.2024.117051

●2024-09-04 Zhongqiao Gan and co-author's  work entitled"Microfluidic-Assisted Pneumatic Droplet Generators Designed for Multiscenario Biomanufacturing with Favorable Biocompatibility and Extendibility"has been published in ACS Biomaterials Science & Engineering.2024, DOI: 10.1021/acsbiomaterials.4c01135

●2024-06-28 Xinyuan Qin and co-author's  work entitled"A Pump-Free Strategy for the Controllable Generation of Alginate Microgels as Cellular Microcarriers"has been published in ACS Biomaterials Science & Engineering.2024, DOI: 10.1021/acsbiomaterials.4c00375

2024-04-30 Three group standards of organ-on-a-chip including "Basic Terminology", "Intestine-on-a-Chip" and "Liver-on-a-Chip" were officially released with the approval of the Chinese Society for Biotechnology. These group standards were led by Dalian Institute of Chemical Physics, Chinese Academy of Sciences. They play a key role in advancing this new technology in science, industry, standardization, and regulatory context of use.

●2024-02-22 Yaqiong Guo and co-author's  work entitled"A generic pump‐free organ‐on‐a‐chip platform for assessment of intestinal drug absorption"has been published in Biotechnology Journal.2024, DOI: 10.1002/biot.202300390

●2023-12-30 Congratulations to Ming Zhang for successfully completing her doctoral defense.

●2023-10-07 Mengqian Zhao and co-author's  review entitled"Advances in Skeletal Muscle Engineering in Biomedical Research"has been published in Advanced Materials Technologies.2023, DOI: 10.1002/admt.202300595

●2023-10-07 Tingting Tao and co-author's  work entitled"Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression"has been published in Pharmacological Research.2023, DOI: 10.1016/j.phrs.2023.106942

●2023-08-30 Jianhua Qin and co-author's  review entitled"Creating Mini-Pregnancy Models in vitro with Clinical Perspectives"has been published in eBioMedicine.2023, DOI: 10.1016/j.ebiom.2023.104780

●2023-06-22 Peng Wang and co-author's  work entitled"Blood–brain–barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system"has been published in Nature Biomedical Engineering.2023, DOI: 10.1038/s41551-023-01054-w

●2023-06-14 Haitao Liu and co-author's  review entitled"Vascularization of Engineered Organoids"has been published in BMEMat.2023, DOI: 10.1002/bmm2.12031

●2023-06-13 Zhongqiao Gan and co-author's  review entitled"Recent advances in defined hydrogels in organoid research"has been published in Bioactive Materials.2023, DOI: 10.1016/j.bioactmat.2023.06.004

●2023-05-17 Rongkai Cao and co-author's  work entitled"Self-assembled human placental model from trophoblast stem cells in a dynamic organ-on-a-chip system"has been published in Cell Proliferation.2023, DOI: 10.1111/cpr.13469

●2023-05-14 Peng Wang and co-author's  review entitled"Multi-organ microphysiological system: A new paradigm for COVID-19 research"has been published in Organs-on-a-Chip.2023, DOI: 10.1016/j.ooc.2023.100029

●2023-02-19 Yaqing Wang and co-author's  review entitled"Advances in human organoids-on-chips in biomedical research"has been published in Life Medicine.2023, DOI: 10.1093/lifemedi/lnad007

●2022-11-17 Congratulations to Pengwei Deng for successfully completing her doctoral defense.

●2022-10-30 Zhongqiao Gan and co-author's  work entitled"One-Step Generation of Porous GelMA Microgels by Droplet-Based Chaotic Advection Effect"has been published in Advanced Materials Technologies.2022,DOI: 10.1002/admt.202201102

●2022-09-23 Kangli Cui and co-author's  work entitled"Engineering placenta-like organoids containing endogenous vascular cells from human-induced pluripotent stem cells"has been published in Bioengineering & Translational Medicine.2022, DOI: 10.1002/btm2.10390

●2022-06-30 Pengwei Deng and co-author's  work entitled"Fluidic Flow Enhances the Differentiation of Placental Trophoblast-Like 3D Tissue from hiPSCs in a Perfused Macrofluidic Device"has been published in Frontiers in Bioengineering and Biotechnology.2022, DOI: 10.3389/fbioe.2022.907104

●2022-04-16 Congratulations to Wenwen Chen for successfully completing her doctoral defense.

●2022-03-05 Congratulations to Kangli Cui for successfully completing her doctoral defense.

●2022-02-03 Yaqing Wang and co-author's  review entitled"Human organoids and organs-on-chips for addressing COVID-19 challengess"has been published in Advanced Science.2022, DOI: 10.1002/advs.202105187

●2022-01-08 Congratulations to Tingting Tao for successfully completing her doctoral defense.

●2021-11-25 Tingting Tao and co-author's  work entitled"Microengineered multi-organoid system from hiPSCs to recapitulate human liver-islet axis in normal and type 2 diabetes"has been published in Advanced Science.2021, DOI: 10.1002/advs.202103495

●2021-11-23 Kangli Cui and co-author's  work entitled"Establishment of Trophoblast-Like Tissue Model from Human Pluripotent Stem Cells in Three-Dimensional Culture System"has been published in Advanced Science.2021, DOI: 10.1002/advs.202100031

●2021-11-09 Congratulations to Hui Wang in our group for winning the 2021 National Scholarship for Postgraduates.

●2021-11-05 Congratulations to Hui Wang for successfully completing her doctoral defense.

●2021-10-27 Wenwen Chen and co-author's  work entitled"A Protable Device for Simple Exosome Separation from Biological Samples"has been published in Micromachines.2021, DOI: 10.3390/mi12101182

●2021-08-30 Congratulations to Haitao Liu for successfully completing her doctoral defense.

●2021-08-29 Yaqing Wang and co-author's  review entitled"Microfluidic Organs-on-a-Chip for Modeling Human Infectious Diseases"has been published in Account of Chemical Reserch.2021, DOI: 10.1021/acs.accounts.1c00411

●2021-06-22 Congratulations to Wang Hui of our group who won the third prize of Bohai Chemical Industry in 2021.

●2021-05-06 Congratulations to Yaqiong Guo for successfully completing her doctoral defense.

●2021-03-12 Wenwen Chen and co-author's  work entitled "Simple and fast isolation of circulating exosomes with a chitosan modified shuttle flow microchip for breast cancer diagnosis" has been published in Lab on a Chip. 2021, DOI: 10.1039/D0LC01311K.

●2021-01-27 Fan He and co-author's  work entitled "Controllable Fabrication of Composite CoreShell Capsules at a Macroscale as Organoid Biocarriers" has been published in ACS Applied Bio Materials. 2021, DOI: 10.1021/acsabm.0c01441.

●2021-01-06 Hui Wang and co-author's  work entitled "One-Step Generation of Aqueous-Droplet-Filled Hydrogel Fibers as Organoid Carriers Using an All-in-Water Microfluidic System" has been published in ACS Applied Materials & Interfaces. 2021, DOI: 10.1021/acsami.0c20434.

●2020-12-01 Yaqiong Guo and co-author's  work entitled "SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip" has been published in Science Bulletin. 2020, DOI: 10.1016/j.scib.2020.11.015.

●2020-11-28 Congratulations to Yaqing Wang for successfully completing her doctoral defense.

●2020-11-24 Fangchao Yin and co-author's  work entitled "HiPSC-derived multi-organoids on chip system for safety assessment of antidepressant drug" has been published in Lab on a Chip. 2020, DOI: 10.1039/D0LC00921K.

2020-11-17 Peng Wang and co-author's  work entitled "A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection" has been published in Cell Death and Disease. 2020, DOI: 10.1038/s41419-020-03252-9.

●2020-10-24 Min Zhang and co-author's work entitled "Biomimetic Human Disease Model of SARS-CoV-2 Induced Lung Injury and Immune Responses on Organ Chip System" has been published in Advanced Science. 2020, DOI: 10.1002/advs.202002928.

●2020-09-16 Yaqing Wang and co-author's work entitled "Modeling Human Nonalcoholic Fatty Liver Disease (NAFLD) with an Organoids-on-chip System" has been published in ACS Biomaterials Science & Engineering. 2020, DOI: 10.1021/acsbiomaterials.0c00682.

●2020-08-15 Yaqing Wang and co-author's work entitled "One-step synthesis of composite hydrogel capsules to support liver organoids generation from hiPSCs" has been published in Biomaterials Science. 2020, DOI: 10.1039/D0BM01085E.

●2020-07-13 Yujuan Zhu and co-author's work entitled "Amnion-on-a-chip: modeling human amniotic development in mid-gestation from pluripotent stem cells" has been published in Lab on a Chip. 2020, DOI: 10.1039/D0LC00268B.

●2020-07-13 Kangli Cui and co-author's work entitled "Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model" has been published in Microsystems & Nanoengineering. 2020, 6, 49.

●2020-04-25 Hui Wang and co-author's work entitled "Flexible Generation of Multi-Aqueous Core Hydrogel Capsules Using Microfluidic Aqueous Two-Phase System" has been published in Advanced Materials Technologies, 2020, 5, 2000045.

●2020-04-13 Haitao Liu and co-author's work entitled "A Droplet Microfluidic System to Fabricate Hybrid Capsules Enabling Stem Cell Organoid Engineering" has been published in Advanced Science, 2020, 7, 1903739.

●2019-10-31 Wenwen Chen and co-author's work entitled "Microfluidic device for on-chip isolation and detection of circulating exosomes in blood of breast cancer patients" has been published in Biomicrofluidics, 2019, 13, 054113.

●2019-07-08 Our invited progress report entitled " Advances in Hydrogels in Organoids and Organ-on-a-Chip " has been published in Advanced Materials, 2019, DOI: 10.1002/adma.201902042.

●2019-07-04 Our invited review entitled "Microfluidic strategies for label-free exosomes isolation and analysis" has been published in Trends in Analytical Chemistry, 2019, 118, 686-698.

●2019-07-01 Wentao Su and co-author's work entitled "Integrated Microfluidic Device for Enrichment and Identification of Circulating Tumor Cells from the Blood of Patients with Colorectal Cancer" has been published in Disease Markers. 2019, 8945974. DOI: 10.1155/2019/8945974.

● 2019-2-5 Tingting Tao and co-author's work entitled " Engineering human islet organoids from iPSCs using an organ-on-chip platform." has been published in Lab on a Chip, 2019, DOI: 10.1039/C8LC01298A.

● 2018-10-30 Yaqing Wang and co-author's work entitled " In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system." has been published inLab on a Chip, 2018, DOI: 10.1039/c8lc00869h.

● 2018-09-25 Haitao Liu and co-author's work entitled"A Microfluidic Strategy for Controllable Generation of WaterinWater Droplets as Biocompatible Microcarriers."has been published inSmall, 2018, 14(36):1801095

● 2018-09-21 The research of Organs-on-chips in DICP continues to attract international attention.

● 2018-08-22 Dr. Yujuan Zhu and co-author's work entitled "Placental Barrier-on-a-Chip: Modeling Placental Inflammatory Responses to Bacterial Infection." was recently published in the journal of ACS Biomaterials Science & Engineering (2018, DOI:10.1021/acsbiomaterials.8b00653), and highlighted byScience Daily.

● 2018-08-22 Min Zhang and co-author's work entitled“A 3D human lung-on-a-chip model for nanotoxicity testing.”was recently published in the journal of Toxicology Research(2018, DOI: 10.1039/C8TX00156A).

● 2018-07-09 Professor Yuejun Chen, the Institute of Neuroscience, Chinese Academy of Sciences, visited our group and gave a talk entitled "Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson's Disease".

● 2018-06-06Professor Benzhong Tang, the Hong Kong University of Science and Technology, visited our group and gave the DICP 70th Anniversary Lecture ().

● 2018-03-26 Fangchao Yin and co-author's work entitled " Engineering brain organoids to probe impaired neurogenesis induced by cadmium." has been published in ACS Biomaterials Science & Engineering as a front cover (2018, 4(5),1908-1915).

● 2018-02-06 Yaqing Wang and co-author's work entitled " Human brain organoid-on-a-chip to model prenatal nicotine exposure." has been published in Lab on a Chip (2018, 18(6),851-860).

● 2018-01-19Kam W. Leong, Member of the National Academy of Engineering, visited our group and gave a talk“Bioengineering of Direct Cell Reprogramming".

● 2017-12-26Professor Jianhua Qin was invited to attend the Xiangshan Science Conferences and give a keynote report on "Human Organs-on-Chips".

● 2017-09-05 Li Zhongyu completed his oral defense of Doctor's thesis. Congratulations.

● 2017-06-01 Li Zhongyu and co-author's work entitled" Drug absorption related nephrotoxicity assessment on an intestine-kidney chip." has been published in Biomicrofluidics 11, 034114 (2017); DOI:http://dx.doi.org/10.1063/1.4984768.

● 2017-05-22 Wang Li and co-author's work entitled" A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice." has been published inLab on a Chip (2017,17(10):1749-1760).

● 2017-04-07 Li Zhongyu and co-author's work entitled" Assessment of cadmium-induced nephrotoxicity using a kidney-on-a-chip device." has been published in Toxicology Research (2017, 6, 372-380).

● 2017-01-09 Xu Hui completed her oral defense of Doctor's thesis. Congratulations.

● 2016-12-05Our organ-on-chip work entitled "A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors" was published in Scientific report 2016, DOI: 10.1038/srep36670.

● 2016-11-18 Yue Yu completed his oral defense of Doctor's thesis. Congratulations.

● 2016-11-17 Ph.D candidate Yue Yu won the Lu Jiaxi outstanding graduate student award 2016. Congratulations.

● 2016-10-10 Xu Hui and co-author's work entitled "A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumor." has been accepted for publishing in Scientific Reports (DOI: 10.1038/srep36670).

● 2016-08-25 Li Zhongyu and co-author's work entitled " Assessment of metabolism-dependent drug efficacyand toxicity on a multilayer organs-on-a-chip." has been published in Integrative Biology as a front cover (2016,8,1022-1029).

● 2016-08-19 Welcome Haitao Liu and Hui Wang to join our group as new students.

● 2016-07-05 Dr Guido Kemeling, Chief editor of ChemSusChem, and Dr.Jose Oliveira, Chief editor of Small, visited our group and carried on further communication with lab members.

● 2016-07-04 Welcome Dr. Hao Yu to join our team.

● 2016-07-04 Prof. Chunying Chen was invited to visit our lab and give a talk about "The Synergistic Strategies for Treatment of Tumor Stem Cell and Nanodrugs".

● 2016-07-02 Prof. Jianbin Huang from Peking University visited our group and gave a talk titled "Multi-scale Self-assembly of Amphiphilic Molecules andCyclodextrin".

● 2016-06-07 Prof. Baoli Zhu from Institute of Microbiology visited our group and gave a talk entitled "Human Gut Microbiome and Accurate Medicine".

2016-05-31 Yu Yue and co-author's work entitled " Simple Spinning of Heterogeneous Hollow Microfibers on Chip " has been accepted for publishing in Advanced Materials (DOI 10.1002/adma.201601504).

● 2016-05-25 Prof. David A. Weitz from Harvard University visited our group and gave a talk titled " Droplet-based Microfluidics for Precision Medicine ".

● 2016-05-02 Li Wang's work-“Human induced pluripotent stem cells derived endothelial cells mimicking vascular inflammatory response under flow” was published in Biomicrofluidics.

● 2016-04-25 Ph.D students Yaqing Wang and Yaqiong Guo attended MMB 2016 held in Seoul, Korea (Apr 20-22, 2016) and gave poster presentations.

● 2016-04-18 Welcome group members Hui Liu, Ying Dou, Li Yu, Pengli Cui and Yi Xie.

● 2015-10-30 Ph.D students Cong Xu andZhongyu Li attended MicroTAS 2015 held in Gyeongju, Korea (Oct 25-29, 2015) and gave oral and poster presentations.

● 2015-10-21 Ph.D candidate Yue Yu won the national scholarship for graduate students. Congratulations!

● 2015-09-18 Li Wang's work-“Human induced pluripotent stem cell-derived beating cardiac tissues on paper” was published as a cover in Lab chip.

● 2015-05-20 Ph.D candidate Yue Yu won the Yanchang scholarship. Congratulations!

● 2015-05-18 Xu Zhang's work-"Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues" was published in Small,which was highlighted by website of MaterialsViewsChina.

● 2015-03-12 Welcome new group members Chun LiKe Feng and Xuanwen Bao.

● 2015-03-11 Hui Xu’s work-“Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy” was accepted by Oncotarget.

● 2015-03-10 Yang Shi's work-“Hypoxia Combined with Spheroid Culture Improves Cartilage Specific Function in Chondrocytes” was published as cover in Integrative Biology.

● 2015-02-13 Hui Wen's work- “A Droplet Microchip with Substance Exchange Capability for the Developmental Study of C. elegans” was published in Lab on a chip.

● 2014-12-15 Prof. Jianhua Qin was elected as the Fellow of the Royal Society of Chemistry (FRSC).http://www.dicp.ac.cn/xwzx/zhxw/201412/t20141215_4275264.html.

● 2014-08-03 The "Lab on a Chip Industry Workshop–Microfluidic Applications" co-hosted by DICP and RSC was closed successfully.http://www.dicp.cas.cn/xwzx/xshd/201408/t20140813_4184357.html

● 2014-05-20 The "Lab on a Chip Industry Workshop–Microfluidic Applications" co-hosted by DICP and RSC will be held on August, 2-3, Dalian, China. More information is available on the website:http://www.locchina.com

● 2014-03-30 The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences(MicroTAS 2014)will be held in USA, October 26-30, 2014. The abstract submission deadline is April 15, 2014.http://www.microtas2014.org

● 2013-12-18 Yue Yu's work about biomimetic synthesis of bamboo-like microfibers was accepted by Advanced Materials

● 2013-11-01 PhD students Yue Yu and Xu Zhang attended MicroTAS 2013 held in Freiburg, Germany (Oct 27-31, 2013) and gave oral and poster presentations, respectively.

● 2013-10-27 Hui Wen's work about aging worm on a chip was published as cover in Integrative Biology

● 2013-09-01 Welcome Simon Lykkemark (Denmark), Zhongyu Li, Guoli Zhu, Tingting Tao, Yingyi Li, Kun Sheng and Yueyue Fu as new students in our group

● 2013-07-20 Congratulations to Ph.D student Jingyun Ma, who won the Yanchang award

● 2012-08-03 Congratulations to Ph.D student Xinghua Gao, who won DICP-Corning prize

● 2013-04-02 Dr. Zhaoxu Meng's research on "Microfluidic-based photocatalytic microreactor using electrospun nanofibrous TiO2 as photocatalyst" was accepted in the Journal of Nanoscale

● 2013-02-26 Research on microfluidic approach to the biomimetic synthesis of a honeycomb material with biological functionality was published as back cover inSmall, which was highlighted byLab on a chip,Noteworthy Chemistry(ACS)andwebsite of MaterialsViewsChina

● 2013-02-13 Ms. Yang Shi's work about "High throughput generation and trapping of individual agarose microgel using microfluidic approach " was accepted in Microfluidics and Nanofluidics

● 2013-01-08 Ms. Huipeng Ma's review about "biomimetic tumor microenvrionment on a chip" was published in the Journal of Biomicrofluidics

● 2012-11-08 Prof. Dr. Roland Zengerle from University of Freiburg visited our group and gave a talk titled "Microfluidic Apps on Standard Lab-Instruments"

● 2012-08-27 Prof. Jiandong Huang from the University of Hongkong visited our group and gave a talk titled "synthetic patterns: sequential establishment of stripe patterns in an expanding cell population"

● 2012-08-03 Congratulations to Ph.D student Xinghua Gao, who won DICP-Corning prize

● 2012-07-29 Congratulations to Ph.D student Huipeng Ma, who won the Yanchang award

● 2012-07-23 Welcome Dr. Wentao Su to join our lab as a postdoc

● 2012-07-12 Prof. Jianhua Qin was appointed as associate editor in Lab on a Chip

2012-05-23 The 3th International Conference on Advances in Microfluidics and Nanofluidics (AMN 2012) was open

● 2012-05-22 Congratulations to Dr. Zhaoxu Meng, who received the postdoc scholarship

2012-04-10 Dr. Jiang et,al. have made new progress in the micro-nanofluidic cytology

● 2012-04-10 Dr. Jiang's work about "Localized Nanofibers for Cellular Assay" was published in Advanced Materials

● 2012-04-09 Ms. Hui Wen's work about "The Study of Longevity of C.elegans on a Chip" was published in Biomedical Microdevice