We designed a microfluidic device integrated with microvalves for shuttle flow based rapid DNA hybridization. The DNA hybridization time could be reduced to 90s with enhance performance. Four serotypes of Dengue Virus could be distinguished simultaneously in an high throughput format.

Lab on Chip, 2010, 10, 2925–2931

Integrated competitive microfluidic immunoassay

An integrated microfluidic competitive immunoassay system was established for high throughput analysis of clenbuterol. The system enabled the rapid and automated measurement of clenbuterol with less time and sample consumption, offering the potential application for analysis of b-agonists in pharmaceutical industry.

Lab on Chip, 2010, 10, 2925–2931

Recreating C.elegans Parkinson's Model on Chip

We proposed a droplet microfluidic platform consisting of a simple droplet trapping array and a tapered immobilization channel array, which enabled to recreat C.elegans Parkinson's disease model and evaluate the anti-degenerative disease drugs effectively. By using this platform, the multiple responses of worm after exposure to neurotoxin (6-OHDA) could be investigated respectively, including mobility defects, neuron degeneration and oxidative stress.

Lab on a Chip, 2010, 10, 2855-2863