Research

Flexible Fabrication of Biomimetic Bamboo-like Hybrid Microfibers.

We proposed a novel strategy for one-step fabrication of biomimetic bamboo-like hybrid fiberswith flexibility at micro-scale. By combining droplet microfluidics technique with wet-spinning process, biocompatiblemicrofibers were incorporated with various spherical materialsincluding polymerspheresor multicellular spheroids in a controllable manner, indicating the enormous potentials of this approach in materials science, and tissue engineering applications.

Flexible Fabrication of Biomimetic Bamboo-like Hybrid Microfibers.
   Advanced Materials, 2014, 26(16): 2494–2499

Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip.

We probed anti-aging role of polydatin in worms by characterizing lifespan, mobility, oxidative resistance, proteins and genes expression on chip by using a flexible microfluidic device. The established microfluidic platform exhibits flexible operations with multiple functions, which not only supports the individual worm's long-term culture with sufficient nutrients exchanges, but also facilitates worm's mobility monitoring, immobilizing and imaging in a controllable and parallel manner.

Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip.
   Integrative Biology, 2014, 6 (1): 35–43

Induction of epithelial-to-mesenchymal transition in proximal tubular epithelial cells on microfluidic devices.

We developed two microfluidic and compartmental chips that reproduced the fluidic and three-dimensional microenvironment of proximal tubular epithelial cells in vivo. We have established a cell-culture system that mimics the native microenvironment of the proximal tubule to a certain extent. Our data indicates that EMT did occur in epithelial cells that were exposed to serum proteins, and C3a plays an essential role in this pathological process.

Induction of epithelial-to-mesenchymal transition in proximal tubular epithelial cells on microfluidic devices.
   Biomaterials, DOI: S0142-9612(13)01326-4

A simple microfluidic strategy for cell migration assay in an in-vitro wound healing model.

This work presented a simple and novel microfluidic device that allowed a quantitative investigation of the cell migration and cell proliferation behaviors in an in vitro wound-healing model, especially focused on the scratch assay. This approach has the unique capability to create localized cell-free regions in parallel, and facilitate quantitative research on cell migration in the wound-healing process, providing a powerful platform for elucidating the mechanism of cell migration in regeneration medicine.

A simple microfluidic strategy for cell migration assay in an in-vitro wound healing model.
   Wound Repair and Regeneration, 2013, 21(6): 897–903

 

   
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