Representative publications

  • A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice.

    Li Wang,Tingting Tao, Wentao Su, Hao Yu, Yue Yu and Jianhua Qin

    Lab on a Chip, 2017, 17, 1749-1760

  • Assessment of cadmium-induced nephrotoxicity using a kidney-on-a-chip device.

    Zhongyu Li, Lei Jiang, Tingting Tao, Wentao Su, Yaqiong Guo, Hao Yu and Jianhua Qin

    Toxicology Research, 2017, 6, 372-380

  • Probing the Bi-directional Interaction Between Microgliaand Gliomas in a Tumor Microenvironment on a Microdevice.

    Rui Gu, Xu Zhang, Ge Zhang, Tingting Tao, Haibo Yu, Lianqing Liu, Ying Dou, Aiping Li, Jianhua Qin

    Neurochem Res, 2017, 42, 1478–1487

  • Human induced pluripotent stem cell-derived cardiac tissue on a thin collagen membrane with natural microstructures.

    LiWang, XiaoqingZhang, CongXu, HuiLiuJianhuaQin.

    Biomaterials Science, 2016, 4 (11), 1655-1662

  • A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumor.

    Hui Xu, Zhongyu Li, Yue Yu, Saman Sizdahkhani, Winson S. Ho, Fangchao Yin, Li Wang, Guoli Zhu, Min Zhang, Lei Jiang, Zhengping Zhuang, and Jianhua Qin

    Scientific Reports, 2016, 6, 36670

  • Assessment of metabolism-dependent drug efficacyand toxicity on a multilayer organs-on-a-chip.

    Zhongyu Li, Yaqiong Guo, Yue Yu, Cong Xu, Hui Xu, and Jianhua Qin

    Integrative Biology, 2016,8,1022-1029 (Cover image)

  • Simple Spinning of Heterogeneous Hollow Microfiber on Chip.

    Yue Yu, Wenbo Wei, Yaqing Wang, Cong Xu, Yaqiong Guo, Jianhua Qin

    Advanced Materials, 2016, 28(31),6649-+

  • Human induced pluripotent stem cells derived endothelial cells mimicking vascular inflammatory response under flow.

    Li Wang, Meng Xiang, Yingying Liu, Ning Sun, Meng Lu, Yang Shi, Xinhong Wang, Dan Meng, Sifeng Chen, and Jianhua Qin

    Biomicrofluidics, 2016, 014106

  • Patterning hypoxic multicellular spheroids in a 3D matrix –a promising method for anti-tumor drug screening.

    Jingyun Ma, Xu Zhang, Yang Liu, Haibo Yu, Lianqing Liu, Yang Shi, Yanfeng Li and Jianhua Qin

    Biotechnology Journal, 2016,11(1),127-134

  • Modeling type 2 diabetes-like hyperglycemia in C. elegans on a microdevice.

    Guoli Zhu, Fangchao Yin, Li Wang, Wenbo Wei, Lei Jiang and Jianhua Qin

    Integrative Biology, 2016, 8(1), 30-38

  • Bezafibrate–mizoribine interaction: Involvement of organic anion transporters OAT1 and OAT3 in rats.

    Yuan Feng , Changyuan Wang, Qi Liu, Qiang Meng, Xiaokui Huo, Zhihao Liu, Pengyuan Sun,Xiaobo Yang, Huijun Sun, Jianhua Qin, Kexin Liu

    European Journal of Pharmaceutical Sciences, 2016, 81,119–128

  • Human induced pluripotent stem cell-derived beating cardiac tissues on paper.

    Li Wang, Cong Xu, Yujuan Zhu, Yue Yu, Ning Sun, Xiaoqing Zhang, Ke Feng and Jianhua Qin

    Lab Chip, 2015,15, 4283-4290(Cover image)

  • Controlled H2O2 release via long-lived electron-hole separation mediated to induce tumor cell apoptosis.

    Cong Wang, Xinghua Gao, Yibo Gao, Wenbin Cao, Jinxuan Tian, Xiaoxiao Wu, Ziran Ye, Xiping Zeng, Jun Wan, Jinbo Wu, Zhengyu Fang, BingPu Zhou, Jianhua Qin and Weijia Wen

    Journal of Materials Chemistry B, 2015,3, 8115-8122

  • Progress of Microfluidics-based Immunoassays in Detection of Cardiac Markers.

    SU Wentao, FENG Ke, QIN Jianhua

    Chinese Journal of Analytical Chemistry, 2015(10),1490-1498

  • Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues.

    Xu Zhang, Zhaoxu Meng, Jingyun Ma, Yang Shi, Hui Xu, Simon Lykkemark and Jianhua Qin

    Small, 2015, 11(30),3666-3675

  • Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy.

    Hui Xu, Shervin Rahimpour, Cody L. Nesvick, Xu Zhang, Jingyun Ma, Min Zhang, Ge Zhang, Li Wang, Chunzhang Yang, Christopher S. Hong, Anand V. Germanwala, J. Bradley Elder, Abhik Ray-Chaudhury, Yu Yao, Mark R. Gilbert, Russell R. Lonser, John D. Heiss, Roscoe O. Brady, Ying Mao, Jianhua Qin and Zhengping Zhuang

    Oncotarget, 2015,6(14),11882-11893

  • Hypoxia Combined with Spheroid Culture Improves Cartilage Specific Function in Chondrocytes.

    Yang Shi, Jingyun Ma, Xu Zhang, Hongjing Li, Lei Jiang and Jianhua Qin

    Integrative Biology, 2015, 7, 289 – 297(Cover image)

  • A Droplet Microchip with Substance Exchange Capability for the Developmental Study of C. elegans.

    Hui Wen, Yue Yu, Guoli Zhu, Lei Jiang and Jianhua Qin

    Lab on a Chip, 2015, 15(8),1905-1911

  • Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-a-induced VCAM-1, ICAM-1and EL expression via the NF-kB pathway.

    Shan Wu, Hui Xu, Jinyong Peng, Changyuan Wang, Yue Jin, Kexin Liu, Huijun Sun, Jianhua Qin

    Biochimie, 2015, 110, 62-72

  • Regulating cell behaviors on micropillar topographies affected by interfacial energy.

    Xinghua Gao, Yeung Yeung Chau, Jiao Xie, Jun Wan, Yanxiao Ren, Jianhua Qin and Weijia Wen

    RSC Adv., 2015, 5, 22916-22922

  • Regulation of cell migration and osteogenic differentiation in mesenchymal stem cells under extremely low fluidic shear stress.

    Xinghua Gao, Xu Zhang, Hui Xu, Bingpu Zhou, Weijia Wen, and Jianhua Qin

    Biomicrofluidics, 2014,8, 052008

  • Microfluidic platform towards point-of-care diagnostics in infectious diseases.

    Wentao Su, Xinghua Gao, Lei Jiang and Jianhua Qin

    Journal of Chromatography A, 2015, 13-26

  • Flexible Fabrication of Biomimetic Bamboo-like Hybrid Microfibers.

    Yu Y, Wen H, Ma JY, Lykkemark S, Xu H, Qin JH

    Advanced Materials, 2014, 26(16): 2494–2499 (Cover image)

  • Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip.

    Wen H, Gao XH, Qin JH

    Integrative Biology, 2014, 6 (1): 35–43 (Cover image)

  • Induction of epithelial-to-mesenchymal transition in proximal tubular epithelial cells on microfluidic devices.

    Zhou MY, Ma HP, Lin HL, Qin JH

    Biomaterials, 2014, 35: 1390-1401

  • A simple microfluidic strategy for cell migration assay in an in-vitro wound healing model.

    Zhang M, Li HJ, Ma HP, Qin JH

    Wound Repair and Regeneration, 2013, 21(6): 897–903

  • Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles.

    Wang X, Li SB, Wang LM, Yi X, Hui YS, Qin JH, Wen WJ

    Journal of Nanomaterials, 2013, ID 864584

  • A high efficiency microfluidic-based photocatalytic microreactor using electrospun nanofibrous TiO2 as photocatalyst.

    Meng ZX, Zhang X, Qin JH

    Nanoscale, 2013, 5, 4687-4690

  • Facile Synthesis of Biomimetic Honeycomb Material with Biological Functionality.

    Ma JY, Hui YS, Zhang M, Yu Y, Wen WJ, Qin JH

    Small, 2013, 9(4), 497–503 (Cover image)

  • An integrated microfluidic device for characterizing chondrocyte metabolism in response to distinct levels of fluid flow stimulus.

    Zhong WL, Ma HP, Wang SY, Gao XH, Zhang WG, Qin JH

    Microfluidics and Nanofluidics,2013, 15(6): 763-773

  • High throughput generation and trapping of individual agarose microgel using microfluidic approach.

    Shi Y, Gao XH, Chen LQ, Zhang M, Ma JY, Zhang XX, Qin JH

    Microfluidics and Nanofluidics,2013, 4, 467-474

  • Biomimetic tumor microenvironment on a microfluidic platform.

    Ma HP, Xu H, Qin JH

    Biomicrofluidics,2013, 7, 011501

  • Simple localization of nanofiber scaffolds via SU-8 photoresist and their use for parallel 3D cellular assays.

    Jiang L, Zhang M, Li JX, Wen WJ, Qin JH.

    Advanced Materials 2012, 24(16), 2191-2195

  • Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices.

    Ma HP, Zhang M, Qin JH.

    Integrative Biology 2012, 4(5):522-530.

  • A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime.

    Zhang Q, Liu TJ, Qin JH.

    Lab on a chip 2012, 12:2837-2842.

  • Multiparameter evaluation of the longevity in C. elegans under stress using an integrated microfluidic device.

    Wen H, Shi WW, Qin JH.

    Biomed Microdevices 2012, 14(4):721-728.

  • Microalgal motility measurement microfluidic chip for toxicity assessment of heavy metals.

    Zheng GX, Wang YH, Qin JH

    Analytical and Bioanalytical Chemistry,2012, 404(10), 3061-3069

  • Flexible generation of gradient electrospinning nanofibers using a microfluidic assisted approach.

    Zhang X, Gao XH, Jiang L, and Qin JH.

    Langmuir 2012, 28(26):10026-10032.

  • Analysis of Caenorhabditis elegans in microfluidic devices.

    Wen H, Qin JH.

    SCIENCE CHINA (Chemistry) 2012, 55(4), 484-493

  • Fast detection of genetic information by an optimized PCR in an interchangeable chip.

    Wu JB, Kodzius R, Xiao K, Qin JH, Wen WJ.

    Biomedical Microdevices 2012, 14(1):179-186.

  • Synthesis of shape-controlled particles based on synergistic effect of geometry confinement, double emulsion template, and polymerization quenching.

    Zhang QQ, Lin BC, Qin JH.

    Microfluidics and Nanofluidics 2012, 12(1-4):33-39.

  • Nanofiber-modified surface directed cell migration and orientation in microsystem.

    Zhang X, Gao X, Jiang L, Zhang XL, Qin JH.

    Biomicrofluidics 2011, 5(3) :032007

  • Patterning cell using Si-stencil for high-throughput assay.

    Wu JB, Zhang MY, Chen LQ, Yu Vivian, Wong Joseph Tin-Yum, Zhang XX, Qin JH, Wen WJ.

    RSC Advances 2011, 1(5):746-750.

  • Controllable synthesis of anisotropic elongated particles using microvalve actuated microfluidic approach.

    Zhang QQ, Zeng SJ, Lin BC, Qin JH.

    Journal of Materials Chemistry 2011, 21(8):2466-2469.

  • Microdroplet-based universal logic gates by electrorheological fluid.

    Zhang M, Wang L, Wang X, Wu J, Li J, Gong X, Qin J, Li W, Wen WJ

    Soft Matter 2011, 7(16):7493-7497.

  • A simple elastic membrane-based microfluidic chip for the proliferation and differentiation of mesenchymal stem cells (MSCs) under tensile stress.

    Gao XH, Zhang X, Tong HY, Lin BC , Qin JH

    Electrophoresis 2011, 32(23):3431-3436.

  • Microfluidic Platform for the Study of Caenorhabditis elegans.

    Shi WW, Wen H, Lin BC, Qin JH.

    Topics in current chemistry 2011, 304:323-338.

  • Patterned Paper as a Low-Cost, Flexible Substrate for Rapid Prototyping of PDMS Microdevices via "Liquid Molding".

    Lu Y, Lin BC, Qin JH.

    Analytical Chemistry 2011, 83(5):1830-1835.

  • Electrical Control of Individual Droplet Breaking and Droplet Contents Extraction.

    Zeng SJ, Pan XY, Zhang QQ, Lin BC, Qin JH.

    Analytical Chemistry 2011, 83(6):2083-2089.

  • Droplet microfluidics for characterizing the neurotoxin-induced responses in individual Caenorhabditis elegans.

    Shi WW, Wen H, Lu Y, Shi Y, Lin BC, Qin JH.

    Lab on a Chip 2010, 10(21).2855-2863.

  • Wax-bonding 3D microfluidic chips.

    Gong XQ, Yi X, Xiao K, Li SB, Kodzius R, Qin JH, Wen WJ.

    Lab on a Chip 2010, 10(19).2622-2627.

  • Microvalve and micropump controlled shuttle flow microfluidic device for rapid DNA hybridization.

    Huang SQ, Li CY, Lin B, Qin J.

    Lab on a Chip 2010, 10(21).2925-2931.

  • The Effects of Insulin-Like Growth Factor-1 and Basic Fibroblast Growth Factor on the Proliferation of Chondrocytes Embedded in the Collagen Gel Using an Integrated Microfluidic Device.

    Li YC, Qin JH, Lin BC, Zhang WG.

    Methods 2010, 16(6).1267-1275.

  • Embellishment of microfluidic devices via femtosecond laser micronanofabrication for chip functionalization.

    Wang J, He Y, Xia H, Niu L-G, Zhang R, Chen QD, Zhang YL, Li YF, Zeng SJ, Qin JH,Lin BC, Sun HB.

    Lab on a Chip 2010, 10(15):1993-1996.

  • Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device.

    Liu TJ, Lin BC, Qin JH.

    Lab on a Chip 2010, 10(13).1671-1677.

  • Characterization of the interaction between fibroblasts and tumor cells on a microfluidic co-culture device.

    Ma HP, Liu TJ, Qin JH, Lin B.

    Electrophoresis 2010, 31(10).1599-1605.

  • A simple photolithography method for microfluidic device fabrication using sunlight as UV source.

    Ma JY, Jiang L, Pan XY, Ma HP, Lin BC, Qin JH.

    Microfluidics and Nanofluidics 2010, 9(6).1247-1252

  • A microfluidic device integrated with multichamber polymerase chain reaction and multichannel separation for genetic analysis.

    Pan X, Jiang L, Liu K, Lin BC, Qin JH.

    Analytica Chimica Acta 2010, 674(1).110-115.

  • Microfluidic devices for characterizing the agonist of formyl peptide receptor in RBL-FPR cells.

    Ye NN, Wang MW, Qin JH, Lin BC.

    Biomedical Microdevices 2010, 12(3).513-521.

  • Fabrication and Characterization of Paper-Based Microfluidics Prepared in Nitrocellulose Membrane By Wax Printing.

    Lu Y, Shi WW, Qin JH, Lin BC.

    Analytical Chemistry 2010, 82(1).329-335.

  • Microvalves actuated sandwich immunoassay on an integrated microfluidic system.

    Gao XH, Jiang L, Su XO, Qin JH, Lin BC.

    Electrophoresis 2009, 30(14).2481-2487.

  • An Immobilized Lipase Microfluidic Reactor for Enantioselective Hydrolysis of Ester.

    Gao Y, Zhong RT, Qin JH, Lin BC.

    Chemistry Letters 2009, 38(3).262-263.

  • Integrated microfluidic immunoassay for the rapid determination of clenbuterol.

    Kong J, Jiang L, Su X, Qin J, Du Y, Lin B.

    Lab on a Chip 2009, 9(11).1541-1547.

  • Rapid nanoliter DNA hybridization based on reciprocating flow on a compact disk microfluidic device.

    Li CY, Dong XL, Qin JH, Lin BC.

    Analytica Chimica Acta 2009, 640(1-2).93-99.

  • Rapid discrimination of single-nucleotide mismatches based on reciprocating flow on a compact disc microfluidic device.

    Li CY, Li HJ, Qin JH, Lin BC.

    Electrophoresis 2009, 30(24).4270-4276

  • A microfluidic device for characterizing the invasion of cancer cells in 3-D matrix.

    Liu TJ, Li CY, Li H, Zeng SJ, Qin H, Lin BC.

    Electrophoresis 2009, 30(24).4285-4291.

  • A facile "liquid-molding'' method to fabricate PDMS microdevices with 3-dimensional channel topography.

    Liu X, Wang Q, Qin JH, Lin BC.

    Lab on a Chip 2009, 9(9).1200-1205.

  • Rapid prototyping of paper-based microfluidics with wax for low-cost, portable bioassay.

    Lu Y, Shi WW, Jiang L, Qin JH, Lin BC.

    Electrophoresis 2009, 30(9).1497-1500.

  • Low cost, portable detection of gold nanoparticle-labeled microfluidic immunoassay with camera cell phone.

    Lu Y, Shi WW, Qin JH, Lin BC.

    Electrophoresis 2009, 30(4).579-582.

  • Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device.

    Ma B, Zhang GH, Qin JH, Lin BC.

    Lab on a Chip 2009, 9(2).232-238.

  • A programmable microvalve-based microfluidic array for characterization of neurotoxin-induced responses of individual C. elegans.

    Ma H, Jiang L, Shi WW, Qin JH, Lin BC.

    Biomicrofluidics 2009, 3(4). 044114

  • A splicing model-based DNA-computing approach on microfluidic chip.

    Xie H, Li BW, Qin JH, Huang ZD, Zhu YS, Lin BC.

    Electrophoresis 2009, 30(20).3514-3518.

  • Microvalve-actuated precise control of individual droplets in microfluidic devices.

    Zeng SJ, Li BW, Su XO, Qin JH, Lin BC.

    Lab on a Chip 2009, 9(10).1340-1343.

  • Microfluidic droplet trapping array as nanoliter reactors for gas-liquid chemical reaction.

    Zhang QQ, Zeng SJ, Qin JH, Lin BC.

    Electrophoresis 2009, 30(18).3181-3188.

  • A microfluidic DNA computing processor for gene expression analysis and gene drug synthesis.

    Zhang Y, Yu H, Qin JH, Lin BC.

    Biomicrofluidics 2009, 3(4). 044105

  • Simply and reliably integrating micro heaters/sensors in a monolithic PCR-CE microfluidic genetic analysis system.

    Zhong R, Pan X, Jiang L, Dai Z, Qin J, Lin B.

    Electrophoresis 2009, 30(8).1297-1305.

  • Microfluidic device for integrated restriction digestion reaction and resulting DNA fragment analysis.

    Xie H, Li BW, Zhong RT, Qin JH, Zhu YS, Lin BC.

    Electrophoresis 2008, 29(24).4956-4963.

  • Simple, fast and high-throughput single-cell analysis on PDMS microfluidic chips.

    Yu L, Huang H, Dong X, Wu DP, Qin JH, Lin BC.

    Electrophoresis 2008, 29(24).5055-5060.

  • Droplet-based microfluidic system for individual Caenorhabditis elegans assay.

    Shi WW, Qin JH, Ye NN, Lin BC.

    Lab on a Chip 2008, 8(9).1432-1435.

  • Electrophoretic separations on microfluidic chips.

    Wu DP, Qin JH, Lin BC.

    Journal of Chromatography A 2008, 1184(1-2).542-559.

  • Microfluidic chip-based cell electrophoresis with multipoint laser-induced fluorescence detection system.

    Yu LF, Shen Z, Mo J, Dong XL, Qin JH, Lin BC.

    Electrophoresis 2007, 28(24).4741-4747.

  • Fabrication of two-weir structure-based packed columns for on-chip solid-phase extraction of DNA.

    Zhong RT, Liu DY, Yu LF, Ye NN, Dai ZP, Oin JH, Lin BC.

    Electrophoresis 2007, 28(16).2920-2926.

  • Quantitative evaluation of the interaction between netropsin and double stranded oligodeoxynucleotides by microfabricated capillary array electrophoresis.

    Shen Z, Liu XJ, Zhou XM, Liang AY, Wu DY, Yu LF, Dai ZP, Qin JH, Lin BC.

    Journal of Separation Science 2007, 30(10).1544-1548.

  • Characterizing doxorubicin-induced apoptosis in HepG2 cells using an integrated microfluidic device.

    Ye NN, Qin JH, Shi WW, Lin BC.

    Electrophoresis 2007, 28(7).1146-1153.

  • Development of a universal serial bus-powered mini-high-voltage power supply for microchip electrophoresis.

    Jiang L, Jiang X, Lu Y, Dai Z, Xie M, Qin JH, Lin BC.

    Electrophoresis 2007, 28(8).1259-1264.

  • Self-assembled epoxy-modified polymer coating on a poly(dimethylsiloxane) microchip for EOF inhibition and biopolymers separation.

    Wu DP, Qin JH, Lin BC.

    Lab on a Chip 2007, 7(11).1490-1496.

  • Cell-based high content screening using an integrated microfluidic device.

    Ye NN, Qin JH, Shi WW, Liu X, Lin BC.

    Lab on a Chip 2007, 7(12).1696-1704.

  • Integrated multilayer microfluidic device with a nanoporous membrane interconnect for online coupling of solid-phase extraction to microchip electrophoresis.

    Long ZC, Shen Z, Wu DP, Qin JH, Lin BC.

    Lab on a Chip 2007, 7(12).1819-1824.

  • Maze exploration and learning in C. elegans

    Qin JH, and A.R. Wheeler

    Lab on a Chip 2007, 7, 186-192

  • Integration of nanoporous membranes for sample filtration/preconcentration in microchip electrophoresis.

    Long ZC, Liu DY, Ye NN, Qin JH, Lin BC.

    Electrophoresis 2006, 27(24).4927-4934.

  • Double-cross hydrostatic pressure sample injection for chip CE. Variable sample plug volume and minimum number of electrodes.

    Luo Y, Wu DP, Zeng SJ, Gai HW, Long ZC, Shen Z, Dai ZP, Qin JH, Lin BC.

    Analytical Chemistry 2006, 78(17).6074-6080.

  • Parallel analysis of biomolecules on a microfabricated capillary array chip.

    Shen Z, Liu XJ, Long ZC, Liu DY, Ye NN, Qin JH, Dai ZP, Lin BC.

    Electrophoresis 2006, 27(5-6).1084-1092.

  • Grafting epoxy-modified hydrophilic polymers onto poly(dimethylsiloxane) microfluidic chip to resist nonspecific protein adsorption.

    Wu DP, Zhao BX, Dai ZP, Qin JH, Lin BC.

    Lab on a Chip 2006, 6(7).942-947.

  • Mini-electrochemical detector for microchip electrophoresis.

    Jiang L, Lu Y, Dai ZP, Xie MH, Lin BC.

    Lab on a Chip 2005, 5(9).930-934.

  • Genotyping the-6A/G functional polymorphism in the core promoter region of angiotensinogen gene by microchip electrophoresis.

    Qin JH, Liu ZY, Wu DP, Zhu N, Zhou XM, Fung YS, Lin BC.

    Electrophoresis 2005, 26(1).219-224.

  • Microfluidic devices for the analysis of apoptosis.

    Qin JH, Ye NN, Liu X, Lin BC.

    Electrophoresis 2005, 26(19).3780-3788.

  • Simultaneous and ultrarapid determination of reactive oxygen species and reduced glutathione in apoptotic leukemia cells by microchip electrophoresis.

    Qin JH, Ye NN, Yu LF, Liu DY, Fung YS, Wang W, Ma XJ, Lin BC.

    Electrophoresis 2005, 26(6).1155-1162.